A double blind comparative study on the efficacy of S 6472, cefaclor in the treatment of bacterial bronchitis

Shinichi Oshima, Yoko Yokoyama, Tsuyoshi Kikuiri, Tadashi Murakami, Hisashi Nishihara, Tatsunori Shimizu, Morikuni Abe, Yoshio Kurihara, Choei Itoh, Keisuke Takeuchi, Osamu Yajima, Mikihiko Tango, Einosuke Odagaki, Yoshiaki Ichishima, Akira Saitoh, Kiyofumi Ishikawa, Akira Suzuki, Mitsuo Asagawa, Mitsunari Nakamura, Mitsuhide OhmichiYomei Hiraga, Kohki Kikuchi, Asako Yamamoto, Ichiroh Nakayama, Masumi Tomisawa, Akio Hirayama, Soichiro Uehara, Yohtaroh Oyama, Kyuichiro Sekine, Tohru Natsuisaka, Takehito Nakabayashi, Takahisa Saitoh, Tetsushi Koroku, Hiroshi Kon, Takashi Nakazato, Toshio Kirisawa, Hiroshi Takagi, Katsuo Suzuki, Mikiya Satoh, Fumio Nagahama, Rensuke Kuroda, Fumiei Kondo, Yoichi Gocho, Koichi Nasuhara, Takashi Takahori, Hiroyuki Tokunaka, Akira Ujiie, Masahide Shinohara, Ikuo Fukuhara, Jutaro Shimomura, Ryohji Ohhashi, Sokichi Onodera, Eiichi Sakai, Tetsuo Shimizu, Nobuhiro Sasaki, Yuji Ikeda, Yoshiro Ishii, Matsumi Tosaka, Hajime Watanabe, Hidetoshi Shibaki, Takehisa Chimoto, Yoshitaka Sugawara, Kazuo Takebe, Katsuhiro Okamoto, Syuichiro Yoshida, Teruo Nakamura, Yoshihiro Kumasaka, Tatsuro Irie, Tadashi Miyazawa, Masashi Yoneda, Naoyoshi Masaki, Toyoichi Tamura, Kohzo Kurahashi, Yuichi Hirai, Hitoshi Yashiro, Norihiko Hirota, Masao Tamura, Takashi Itoh, Shigeki Mori, Fumitoshi Yamauchi, Kiyoshi Omuro, Yutaka Ishikawa, Takashi Tsuruya, Hiroshi Kuramitsu, Kotaro Itakura, Yasuyuki Suzuki, Kazutoshi Gomi, Katsuyoshi Moriya, Nobuhisa Satoh, Mikio Matsui, Norimi Maiya, Masao Satoh, Yoshikatsu Nemoto, Kiyoshi Kawamorita, Noboru Asoh, Tsukasa Yoshida, Hiroyoshi Yaoi, Masaaki Itazawa, Syuji Chiba, Saburo Shindoh, Mamoru Furuta, Kiichi Kaishio, Hidetaka Satoh, Kazuo Satoh, Kiyoshi Konno, Kotaro Oizumi, Masako Sasaki, Akira Watanabe, Seiichi Aonuma, Kikuo Ohnuma, Yushi Nakai, Kohsaku Nagai, Tokuji Honda, Fumio Ariji, Ichiro Yoshida, Kazuo Wakasa, Moriaki Nishina, Ryosuke Saeki, Teruo Hasuike, Izumi Hayashi, Tsugushi Ito, Shigeo Takizawa, Yuzuru Matsumoto, Shigemi Kohsaka, Kenkichi Shikanai

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Clinical efficacy and safety of S 6472 (long active cefaclor (CCL)) and CCL were compared by a double-blind study using 248 patients with bacterial bronchitis. Patients were orally administered with either 375 mg of S 6472 2 times or 250 mg of CCL 3 times daily for 7 days, and the following results were obtained. 1. Clinical efficacy judged by a committee: The efficacy rates on acute bronchitis were 87.2% for S 6472 and 82.6% for CCL, and the efficacy rates on chronic bronchitis were 70.3% for S 6472 and 64.7% for CCL. There was no significant difference between the 2 drugs in clinical efficacy. 2. Clinical efficacy judged by doctors in charge: Results of the clinical efficacy judged by doctors in charge were similar to the efficacy judged by the committee. 3. Bacteriological efficacy judged by the committee: Eradication rate for the S 6472 group was 71.1% (32 of 45 patients) and that for the CCL group was 67.4% (29 of 43 patients). There was no significant difference between the 2 drugs in the bacteriological efficacy. 4. Side effects and abnormal laboratory findings: Side effects were observed in 5 cases (4.2%) in the S 6472 group and in 5 cases (4.0%) in the CCL group. These side effects, however, were not serious, and no remarkable abnomal laboratory values were observed. There was no significant difference between the 2 drugs in the incidence of side effects or abnormal laboratory findings. 5. Clinical utility: When the clinical utility was expressed by the utility rate (very useful and useful), it was 79.5% in the S 6472 group (117 patients) and 76.2% in the CCL group (122 patients) (judged by the committee). When the utility was judged by doctors in charge, it was 73.3% in S 6472 group (120 patients) and 71.4% in CCL group (126 patients). From the above results, it has been concluded that S 6472 taken twice daily is equivalent to CCL in effectiveness on bacterial bronchitis.

    Original languageEnglish
    Pages (from-to)2726-2753
    Number of pages28
    JournalThe Japanese Journal of Antibiotics
    Volume39
    Issue number10
    DOIs
    Publication statusPublished - 1986 Oct

    ASJC Scopus subject areas

    • Microbiology (medical)
    • Pharmacology (medical)
    • Infectious Diseases

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