Abstract
Clinical efficacy and safety of S 6472 (long active cefaclor (CCL)) and CCL were compared by a double-blind study using 248 patients with bacterial bronchitis. Patients were orally administered with either 375 mg of S 6472 2 times or 250 mg of CCL 3 times daily for 7 days, and the following results were obtained. 1. Clinical efficacy judged by a committee: The efficacy rates on acute bronchitis were 87.2% for S 6472 and 82.6% for CCL, and the efficacy rates on chronic bronchitis were 70.3% for S 6472 and 64.7% for CCL. There was no significant difference between the 2 drugs in clinical efficacy. 2. Clinical efficacy judged by doctors in charge: Results of the clinical efficacy judged by doctors in charge were similar to the efficacy judged by the committee. 3. Bacteriological efficacy judged by the committee: Eradication rate for the S 6472 group was 71.1% (32 of 45 patients) and that for the CCL group was 67.4% (29 of 43 patients). There was no significant difference between the 2 drugs in the bacteriological efficacy. 4. Side effects and abnormal laboratory findings: Side effects were observed in 5 cases (4.2%) in the S 6472 group and in 5 cases (4.0%) in the CCL group. These side effects, however, were not serious, and no remarkable abnomal laboratory values were observed. There was no significant difference between the 2 drugs in the incidence of side effects or abnormal laboratory findings. 5. Clinical utility: When the clinical utility was expressed by the utility rate (very useful and useful), it was 79.5% in the S 6472 group (117 patients) and 76.2% in the CCL group (122 patients) (judged by the committee). When the utility was judged by doctors in charge, it was 73.3% in S 6472 group (120 patients) and 71.4% in CCL group (126 patients). From the above results, it has been concluded that S 6472 taken twice daily is equivalent to CCL in effectiveness on bacterial bronchitis.
Original language | English |
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Pages (from-to) | 2726-2753 |
Number of pages | 28 |
Journal | The Japanese Journal of Antibiotics |
Volume | 39 |
Issue number | 10 |
DOIs | |
Publication status | Published - 1986 Oct |
Externally published | Yes |
ASJC Scopus subject areas
- Microbiology (medical)
- Pharmacology (medical)
- Infectious Diseases