A direct and mild formylation method for substituted benzenes utilizing dichloromethyl methyl ether-silver trifluoromethanesulfonate

Kosuke Ohsawa, Masahito Yoshida, Takayuki Doi

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

A silver trifluoromethanesulfonate (AgOTf)-promoted direct and mild formylation of benzenes has been developed. The reaction utilizing dichloromethyl methyl ether (Cl2CHOMe) and AgOTf powerfully formylated various substituted benzenes under temperature conditions as low as -78 C without losing the protecting groups on the phenolic hydroxyl group.

Original languageEnglish
Pages (from-to)3438-3444
Number of pages7
JournalJournal of Organic Chemistry
Volume78
Issue number7
DOIs
Publication statusPublished - 2013 Apr 5

ASJC Scopus subject areas

  • Organic Chemistry

Fingerprint Dive into the research topics of 'A direct and mild formylation method for substituted benzenes utilizing dichloromethyl methyl ether-silver trifluoromethanesulfonate'. Together they form a unique fingerprint.

Cite this