A dimethoxytriazine type glycosyl donor enables a facile chemo-enzymatic route toward α-linked N-acetylglucosaminyl-galactose disaccharide unit from gastric mucin

Masato Noguchi, Miwa Nakamura, Ayaka Ohno, Tomonari Tanaka, Atsushi Kobayashi, Masaki Ishihara, Masaya Fujita, Akiko Tsuchida, Mamoru Mizuno, Shin Ichiro Shoda

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12 Citations (Scopus)

Abstract

An efficient chemo-enzymatic process for construction of the α-linked disaccharide unit (GlcNAcα1-4Gal) found in gastric mucin has been developed. The process consists of a one-step preparation of a novel triazine type glycosyl donor in water and the subsequent transglycosylation to a galactose derivative catalysed by α-N-acetylglucosaminidase.

Original languageEnglish
Pages (from-to)5560-5562
Number of pages3
JournalChemical Communications
Volume48
Issue number45
DOIs
Publication statusPublished - 2012 May 9

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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    Noguchi, M., Nakamura, M., Ohno, A., Tanaka, T., Kobayashi, A., Ishihara, M., Fujita, M., Tsuchida, A., Mizuno, M., & Shoda, S. I. (2012). A dimethoxytriazine type glycosyl donor enables a facile chemo-enzymatic route toward α-linked N-acetylglucosaminyl-galactose disaccharide unit from gastric mucin. Chemical Communications, 48(45), 5560-5562. https://doi.org/10.1039/c2cc30946g