A decrease in the molecular weight of hyaluronic acid in synovial fluid from patients with temporomandibular disorders

Tetsu Takahashi, Kazuhiro Tominaga, Hiroshi Takano, Wataru Ariyoshi, Manabu Habu, Jinichi Fukuda, Hiroshi Maeda

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

BACKGROUND: The molecular weight (MW) of hyaluronic acid (HA) in joints generally declines in inflammatory arthritis. As inflammation exists in certain temperomandibular disorders (TMD), we measured the MW of HA in synovial fluid (SF) recovered from patients with TMD and compared it with that from normal controls. METHODS: Synovial fluid was obtained from patients with TMD (21 TMJs) and normal controls (5 TMJs). The MW of HA was measured using high-performance liquid chromatography (HPLC). RESULTS: In the controls, the MW of HA in SF exceeded the detection limit, 3000 kDa. In contrast, 19 (90.5%) of 21 SF samples from patients showed a decreased MW of HA. The median MW of HA (1570 kDa) in TMD was significantly lower than that in the controls (P < 0.01). CONCLUSION: The MW of HA in SF from patients with TMD is decreased.

Original languageEnglish
Pages (from-to)224-229
Number of pages6
JournalJournal of Oral Pathology and Medicine
Volume33
Issue number4
DOIs
Publication statusPublished - 2004 Apr 1
Externally publishedYes

Keywords

  • Hyaluronic acid
  • Internal derangement
  • Osteoarthritis
  • Synovial fluid
  • Synovial fluid analysis
  • Temporomandibular joint

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oral Surgery
  • Otorhinolaryngology
  • Cancer Research
  • Periodontics

Fingerprint

Dive into the research topics of 'A decrease in the molecular weight of hyaluronic acid in synovial fluid from patients with temporomandibular disorders'. Together they form a unique fingerprint.

Cite this