A database for cell signaling networks

Takako Takai-Igarashi, Yoko Nadaoka, Tsuguchika Kaminuma

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

We developed a data and knowledge base for cellular signal transduction in human cells, to make this rapidly growing information available. The database includes all the biological properties of cellular signal transduction, including biological reactions that transfer cellular signals and molecular attributes characterized by sequences, structures, and functions. Since the database is based on the object-oriented technique, highly flexible methods of data definition and modification are necessary to handle this diverse and complex biological information. The database includes attractive graphical representations of signaling cascades and the three- dimensional structure of molecules. The database is a novel application of ACEDB, which was the database originally developed to store the C. elegans genome. The database can be accessed through the Internet at http://geo.nihs.go.jp/csndb.htm1.

Original languageEnglish
Pages (from-to)747-754
Number of pages8
JournalJournal of Computational Biology
Volume5
Issue number4
DOIs
Publication statusPublished - 1998 Jan 1

Keywords

  • Cellular signal transduction
  • Object-oriented database

ASJC Scopus subject areas

  • Modelling and Simulation
  • Molecular Biology
  • Genetics
  • Computational Mathematics
  • Computational Theory and Mathematics

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    Takai-Igarashi, T., Nadaoka, Y., & Kaminuma, T. (1998). A database for cell signaling networks. Journal of Computational Biology, 5(4), 747-754. https://doi.org/10.1089/cmb.1998.5.747