A convenient procedure for palladium catalyzed cyanation using a unique bidentate phosphorus ligand

Rader S. Jensen, Anil S. Gajare, Kozo Toyota, Masaaki Yoshifuji, Fumiyuki Ozawa

Research output: Contribution to journalArticlepeer-review

84 Citations (Scopus)

Abstract

A palladium complex bearing 1,2-diphenyl-3,4-diphosphinidenecyclobutene ligand (DPCB) has been used to facilitate the catalytic cyanation of aryl bromides. A series of substituted benzonitriles was prepared in good to high yields by the treatment of the corresponding aryl bromides with Zn(CN) 2 in N-methyl-2-pyrrolidone in the presence of 2-4 mol % catalyst at 100°C for 16 h.

Original languageEnglish
Pages (from-to)8645-8647
Number of pages3
JournalTetrahedron Letters
Volume46
Issue number50
DOIs
Publication statusPublished - 2005 Dec 12

Keywords

  • Aryl bromide
  • Catalytic cyanation
  • Low-coordinated phosphorus ligand
  • Palladium catalyst
  • Zinc cyanide

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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