A concise total synthesis of (+)-neopeltolide

Haruhiko Fuwa; Asami Saito; Makoto Sasaki

doi:10.1002/anie.201000624

A concise total synthesis of (+)-neopeltolide

Haruhiko Fuwa, Asami Saito, Makoto Sasaki

Research output: Contribution to journal › Article › peer-review

86 Citations (Scopus)

Abstract

(Figure Presented) Short and sweet: The highly potent antiproliferative marine macrolide (+)-neopeltolide has been synthesized based on the strategic application of olefin metathesis reactions. The total synthesis proceeded in only 13 steps from commercially available starting materials, and represents the shortest synthesis of (+)-neopeltolide reported to date.

Original language	English
Pages (from-to)	3041-3044
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	49
Issue number	17
DOIs	https://doi.org/10.1002/anie.201000624
Publication status	Published - 2010 Apr 12

Keywords

Chemoselectivity
Cyclization
Macrolides
Metathesis
Natural products

ASJC Scopus subject areas

Catalysis
Chemistry(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/anie.201000624

Cite this

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abstract = "(Figure Presented) Short and sweet: The highly potent antiproliferative marine macrolide (+)-neopeltolide has been synthesized based on the strategic application of olefin metathesis reactions. The total synthesis proceeded in only 13 steps from commercially available starting materials, and represents the shortest synthesis of (+)-neopeltolide reported to date.",

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AU - Saito, Asami

AU - Sasaki, Makoto

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N2 - (Figure Presented) Short and sweet: The highly potent antiproliferative marine macrolide (+)-neopeltolide has been synthesized based on the strategic application of olefin metathesis reactions. The total synthesis proceeded in only 13 steps from commercially available starting materials, and represents the shortest synthesis of (+)-neopeltolide reported to date.

AB - (Figure Presented) Short and sweet: The highly potent antiproliferative marine macrolide (+)-neopeltolide has been synthesized based on the strategic application of olefin metathesis reactions. The total synthesis proceeded in only 13 steps from commercially available starting materials, and represents the shortest synthesis of (+)-neopeltolide reported to date.

KW - Chemoselectivity

KW - Cyclization

KW - Macrolides

KW - Metathesis

KW - Natural products

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A concise total synthesis of (+)-neopeltolide

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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