A concise total synthesis of (+)-neopeltolide

Haruhiko Fuwa, Asami Saito, Makoto Sasaki

    Research output: Contribution to journalArticlepeer-review

    77 Citations (Scopus)

    Abstract

    (Figure Presented) Short and sweet: The highly potent antiproliferative marine macrolide (+)-neopeltolide has been synthesized based on the strategic application of olefin metathesis reactions. The total synthesis proceeded in only 13 steps from commercially available starting materials, and represents the shortest synthesis of (+)-neopeltolide reported to date.

    Original languageEnglish
    Pages (from-to)3041-3044
    Number of pages4
    JournalAngewandte Chemie - International Edition
    Volume49
    Issue number17
    DOIs
    Publication statusPublished - 2010 Apr 12

    Keywords

    • Chemoselectivity
    • Cyclization
    • Macrolides
    • Metathesis
    • Natural products

    ASJC Scopus subject areas

    • Catalysis
    • Chemistry(all)

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