A concise total synthesis of (+)-neopeltolide

Haruhiko Fuwa; Asami Saito; Makoto Sasaki

doi:10.1002/anie.201000624

A concise total synthesis of (+)-neopeltolide

Haruhiko Fuwa, Asami Saito, Makoto Sasaki

Research output: Contribution to journal › Article › peer-review

77 Citations (Scopus)

Abstract

(Figure Presented) Short and sweet: The highly potent antiproliferative marine macrolide (+)-neopeltolide has been synthesized based on the strategic application of olefin metathesis reactions. The total synthesis proceeded in only 13 steps from commercially available starting materials, and represents the shortest synthesis of (+)-neopeltolide reported to date.

Original language	English
Pages (from-to)	3041-3044
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	49
Issue number	17
DOIs	https://doi.org/10.1002/anie.201000624
Publication status	Published - 2010 Apr 12

Keywords

Chemoselectivity
Cyclization
Macrolides
Metathesis
Natural products

ASJC Scopus subject areas

Catalysis
Chemistry(all)

Access to Document

10.1002/anie.201000624

Fingerprint Dive into the research topics of 'A concise total synthesis of (+)-neopeltolide'. Together they form a unique fingerprint.

Cite this

@article{d87211385fd245c2a238489061d7628d,

title = "A concise total synthesis of (+)-neopeltolide",

abstract = "(Figure Presented) Short and sweet: The highly potent antiproliferative marine macrolide (+)-neopeltolide has been synthesized based on the strategic application of olefin metathesis reactions. The total synthesis proceeded in only 13 steps from commercially available starting materials, and represents the shortest synthesis of (+)-neopeltolide reported to date.",

keywords = "Chemoselectivity, Cyclization, Macrolides, Metathesis, Natural products",

author = "Haruhiko Fuwa and Asami Saito and Makoto Sasaki",

year = "2010",

month = apr,

day = "12",

doi = "10.1002/anie.201000624",

language = "English",

volume = "49",

pages = "3041--3044",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "17",

}

TY - JOUR

T1 - A concise total synthesis of (+)-neopeltolide

AU - Fuwa, Haruhiko

AU - Saito, Asami

AU - Sasaki, Makoto

PY - 2010/4/12

Y1 - 2010/4/12

N2 - (Figure Presented) Short and sweet: The highly potent antiproliferative marine macrolide (+)-neopeltolide has been synthesized based on the strategic application of olefin metathesis reactions. The total synthesis proceeded in only 13 steps from commercially available starting materials, and represents the shortest synthesis of (+)-neopeltolide reported to date.

AB - (Figure Presented) Short and sweet: The highly potent antiproliferative marine macrolide (+)-neopeltolide has been synthesized based on the strategic application of olefin metathesis reactions. The total synthesis proceeded in only 13 steps from commercially available starting materials, and represents the shortest synthesis of (+)-neopeltolide reported to date.

KW - Chemoselectivity

KW - Cyclization

KW - Macrolides

KW - Metathesis

KW - Natural products

UR - http://www.scopus.com/inward/record.url?scp=77951182592&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77951182592&partnerID=8YFLogxK

U2 - 10.1002/anie.201000624

DO - 10.1002/anie.201000624

M3 - Article

C2 - 20309988

AN - SCOPUS:77951182592

VL - 49

SP - 3041

EP - 3044

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

SN - 1433-7851

IS - 17

ER -