Abstract
(Figure Presented) Short and sweet: The highly potent antiproliferative marine macrolide (+)-neopeltolide has been synthesized based on the strategic application of olefin metathesis reactions. The total synthesis proceeded in only 13 steps from commercially available starting materials, and represents the shortest synthesis of (+)-neopeltolide reported to date.
Original language | English |
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Pages (from-to) | 3041-3044 |
Number of pages | 4 |
Journal | Angewandte Chemie - International Edition |
Volume | 49 |
Issue number | 17 |
DOIs | |
Publication status | Published - 2010 Apr 12 |
Keywords
- Chemoselectivity
- Cyclization
- Macrolides
- Metathesis
- Natural products
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)