A concise synthetic approach to β,γ-dehydrocurvularin: Synthesis of (±)-di-O-methyl-β,γ-dehydrocurvularin

Takuho Miyagi, Shigefumi Kuwahara

    Research output: Contribution to journalArticlepeer-review

    9 Citations (Scopus)


    A concise synthesis of di-O-methyl-β,γ-dehydrocurvularin, the di-O-methylated derivative of the naturally occurring nematicidal macrolide, β,γ-dehydrocurvuralin, was accomplished by starting from a commercially available aromatic carboxylic acid in a three-step sequence consisting of esterification, Friedel-Crafts acylation, and microwave-promoted ring-closing metathesis.

    Original languageEnglish
    Pages (from-to)1592-1594
    Number of pages3
    JournalBioscience, Biotechnology and Biochemistry
    Issue number6
    Publication statusPublished - 2007


    • Curvuralin
    • Macrolide
    • Microwave-promoted reaction
    • Nematicide
    • Ring-closing metathesis

    ASJC Scopus subject areas

    • Biotechnology
    • Analytical Chemistry
    • Biochemistry
    • Applied Microbiology and Biotechnology
    • Molecular Biology
    • Organic Chemistry


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