A concise synthetic approach to β,γ-dehydrocurvularin: Synthesis of (±)-di-O-methyl-β,γ-dehydrocurvularin

Takuho Miyagi, Shigefumi Kuwahara

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


A concise synthesis of di-O-methyl-β,γ-dehydrocurvularin, the di-O-methylated derivative of the naturally occurring nematicidal macrolide, β,γ-dehydrocurvuralin, was accomplished by starting from a commercially available aromatic carboxylic acid in a three-step sequence consisting of esterification, Friedel-Crafts acylation, and microwave-promoted ring-closing metathesis.

Original languageEnglish
Pages (from-to)1592-1594
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Issue number6
Publication statusPublished - 2007


  • Curvuralin
  • Macrolide
  • Microwave-promoted reaction
  • Nematicide
  • Ring-closing metathesis

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry


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