A concise synthesis of the pentacyclic framework of cortistatins

Shuji Yamashita, Kentaro Iso, Masahiro Hirama

Research output: Contribution to journalArticlepeer-review

84 Citations (Scopus)

Abstract

(Chemical Equation Presented) An efficient synthesis of the pentacyclic framework of cortistatins has been developed. The key strategy comprises assembly of the A- and the CD-ring fragments by Knoevenagel reaction, facile formation of the pyran ring via electrocyclization, and construction of the seven-membered B-ring by radical addition to an αβ-unsaturated ketone.

Original languageEnglish
Pages (from-to)3413-3415
Number of pages3
JournalOrganic letters
Volume10
Issue number16
DOIs
Publication statusPublished - 2008

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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