Abstract
Rapid chemical syntheses of [carbonyl‐ 11C]melatonin and N‐[carbonyl‐ 11C]acetylserotonin starting from [11C]carbon dioxide are described. The radiochemical yield (based on [carbonyl‐11C]‐acetic acid), purity, and the specific activity (end of bombardment) of the former are 12%, >98%, and 4.2 Ci/μmol, respectively. The latter is also synthesized with the same radiochemical yield, purity, and specific activity. The total times required for their syntheses are ca. 45 min, respectively.
Original language | English |
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Pages (from-to) | 949-955 |
Number of pages | 7 |
Journal | Journal of Labelled Compounds and Radiopharmaceuticals |
Volume | 29 |
Issue number | 8 |
DOIs | |
Publication status | Published - 1991 Jan 1 |
Keywords
- N‐[carbonyl‐ C]acetylserotonin
- N‐[carbonyl‐ C]acetyl‐5‐methoxytryptamine
- N‐[carbonyl‐C]acetyl‐5‐hydroxytryptamine
- [C]carbon dioxide
- [carbonyl‐ C]Melatonin
ASJC Scopus subject areas
- Analytical Chemistry
- Biochemistry
- Radiology Nuclear Medicine and imaging
- Drug Discovery
- Spectroscopy
- Organic Chemistry