A concise synthesis of [carbonyl‐11C]melatonin and N‐[carbonyl‐ 11C]acetylserotonin

Masao Tada; Atsushi Oikawa; Ren Iwata; Kazunori Sato; Hiroshi Sugiyama; Hiromu Takahashi; Akira Wakui; Hiroshi Fukuda; Kazuo Kubota; Yoshinao Abe; Tatsuo Yamaguchi; Takehiko Fujiwara; Tachio Sato; Tatsuo Ido

doi:10.1002/jlcr.2580290812

A concise synthesis of [carbonyl‐¹¹C]melatonin and N‐[carbonyl‐ ¹¹C]acetylserotonin

Masao Tada, Atsushi Oikawa, Ren Iwata, Kazunori Sato, Hiroshi Sugiyama, Hiromu Takahashi, Akira Wakui, Hiroshi Fukuda, Kazuo Kubota, Yoshinao Abe, Tatsuo Yamaguchi, Takehiko Fujiwara, Tachio Sato, Tatsuo Ido

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Rapid chemical syntheses of [carbonyl‐ ¹¹C]melatonin and N‐[carbonyl‐ ¹¹C]acetylserotonin starting from [¹¹C]carbon dioxide are described. The radiochemical yield (based on [carbonyl‐¹¹C]‐acetic acid), purity, and the specific activity (end of bombardment) of the former are 12%, >98%, and 4.2 Ci/μmol, respectively. The latter is also synthesized with the same radiochemical yield, purity, and specific activity. The total times required for their syntheses are ca. 45 min, respectively.

Original language	English
Pages (from-to)	949-955
Number of pages	7
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	29
Issue number	8
DOIs	https://doi.org/10.1002/jlcr.2580290812
Publication status	Published - 1991 Jan 1

Keywords

N‐[carbonyl‐ C]acetylserotonin
N‐[carbonyl‐ C]acetyl‐5‐methoxytryptamine
N‐[carbonyl‐C]acetyl‐5‐hydroxytryptamine
[C]carbon dioxide
[carbonyl‐ C]Melatonin

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Radiology Nuclear Medicine and imaging
Drug Discovery
Spectroscopy
Organic Chemistry

Access to Document

10.1002/jlcr.2580290812

Cite this

Tada, M., Oikawa, A., Iwata, R., Sato, K., Sugiyama, H., Takahashi, H., Wakui, A., Fukuda, H., Kubota, K., Abe, Y., Yamaguchi, T., Fujiwara, T., Sato, T., & Ido, T. (1991). A concise synthesis of [carbonyl‐¹¹C]melatonin and N‐[carbonyl‐ ¹¹C]acetylserotonin. Journal of Labelled Compounds and Radiopharmaceuticals, 29(8), 949-955. https://doi.org/10.1002/jlcr.2580290812

A concise synthesis of [carbonyl‐¹¹C]melatonin and N‐[carbonyl‐ ¹¹C]acetylserotonin. / Tada, Masao; Oikawa, Atsushi; Iwata, Ren; Sato, Kazunori; Sugiyama, Hiroshi; Takahashi, Hiromu; Wakui, Akira; Fukuda, Hiroshi; Kubota, Kazuo; Abe, Yoshinao; Yamaguchi, Tatsuo; Fujiwara, Takehiko; Sato, Tachio; Ido, Tatsuo.

In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 29, No. 8, 01.01.1991, p. 949-955.

Research output: Contribution to journal › Article › peer-review

Tada, M, Oikawa, A, Iwata, R, Sato, K, Sugiyama, H, Takahashi, H, Wakui, A, Fukuda, H, Kubota, K, Abe, Y, Yamaguchi, T, Fujiwara, T, Sato, T & Ido, T 1991, 'A concise synthesis of [carbonyl‐¹¹C]melatonin and N‐[carbonyl‐ ¹¹C]acetylserotonin', Journal of Labelled Compounds and Radiopharmaceuticals, vol. 29, no. 8, pp. 949-955. https://doi.org/10.1002/jlcr.2580290812

Tada, Masao ; Oikawa, Atsushi ; Iwata, Ren ; Sato, Kazunori ; Sugiyama, Hiroshi ; Takahashi, Hiromu ; Wakui, Akira ; Fukuda, Hiroshi ; Kubota, Kazuo ; Abe, Yoshinao ; Yamaguchi, Tatsuo ; Fujiwara, Takehiko ; Sato, Tachio ; Ido, Tatsuo. / A concise synthesis of [carbonyl‐¹¹C]melatonin and N‐[carbonyl‐ ¹¹C]acetylserotonin. In: Journal of Labelled Compounds and Radiopharmaceuticals. 1991 ; Vol. 29, No. 8. pp. 949-955.

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abstract = "Rapid chemical syntheses of [carbonyl‐ 11C]melatonin and N‐[carbonyl‐ 11C]acetylserotonin starting from [11C]carbon dioxide are described. The radiochemical yield (based on [carbonyl‐11C]‐acetic acid), purity, and the specific activity (end of bombardment) of the former are 12%, >98%, and 4.2 Ci/μmol, respectively. The latter is also synthesized with the same radiochemical yield, purity, and specific activity. The total times required for their syntheses are ca. 45 min, respectively.",

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