A concise synthesis of [carbonyl‐11C]melatonin and N‐[carbonyl‐ 11C]acetylserotonin

Masao Tada, Atsushi Oikawa, Ren Iwata, Kazunori Sato, Hiroshi Sugiyama, Hiromu Takahashi, Akira Wakui, Hiroshi Fukuda, Kazuo Kubota, Yoshinao Abe, Tatsuo Yamaguchi, Takehiko Fujiwara, Tachio Sato, Tatsuo Ido

    Research output: Contribution to journalArticlepeer-review

    2 Citations (Scopus)

    Abstract

    Rapid chemical syntheses of [carbonyl‐ 11C]melatonin and N‐[carbonyl‐ 11C]acetylserotonin starting from [11C]carbon dioxide are described. The radiochemical yield (based on [carbonyl‐11C]‐acetic acid), purity, and the specific activity (end of bombardment) of the former are 12%, >98%, and 4.2 Ci/μmol, respectively. The latter is also synthesized with the same radiochemical yield, purity, and specific activity. The total times required for their syntheses are ca. 45 min, respectively.

    Original languageEnglish
    Pages (from-to)949-955
    Number of pages7
    JournalJournal of Labelled Compounds and Radiopharmaceuticals
    Volume29
    Issue number8
    DOIs
    Publication statusPublished - 1991 Jan 1

    Keywords

    • N‐[carbonyl‐ C]acetylserotonin
    • N‐[carbonyl‐ C]acetyl‐5‐methoxytryptamine
    • N‐[carbonyl‐C]acetyl‐5‐hydroxytryptamine
    • [C]carbon dioxide
    • [carbonyl‐ C]Melatonin

    ASJC Scopus subject areas

    • Analytical Chemistry
    • Biochemistry
    • Radiology Nuclear Medicine and imaging
    • Drug Discovery
    • Spectroscopy
    • Organic Chemistry

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