(Matrix Presented) This report describes a concise enantioselective synthesis of the A-ring synthon for the synthesis of 1α-hydroxyvitamin D3 compounds. The synthesis involves two notable transformations: (i) stereoselective construction of the enol triflate from the vinyl ketone by Michael addition of Ph2P(O)Li followed by in situ triftation of the resulting enolate and (ii) palladium-catalyzed Heck type cyclization of the enol triflate.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry