A concentration-based microscale method for 18F-nucleophilic substitutions and its testing on the one-pot radiosynthesis of [18F]FET and [18F]fallypride

Ren Iwata, Kazunori Terasaki, Yoichi Ishikawa, Ryuichi Harada, Shozo Furumoto, Kazuhiko Yanai, Claudio Pascali

Research output: Contribution to journalArticlepeer-review

Abstract

When applied to a radiosynthesis, a microscale approach can help to save precursor and improve yields. Thus, a 5–10 μL microscale method based on a concentration procedure was developed and applied to the radiosynthesis of [18F]FET and [18F]fallypride. In spite of using an amount of precursor ca. 100 times smaller, radiochemical yields were comparable or even higher than those reported in literature. Because of the very low reaction volumes, the possible effects of concentrated dose of activity and carrier fluoride were also investigated.

Original languageEnglish
Article number109361
JournalApplied Radiation and Isotopes
Volume166
DOIs
Publication statusPublished - 2020 Dec

Keywords

  • Concentration by evaporation
  • Microscale reaction
  • [F]FET
  • [F]fallypride

ASJC Scopus subject areas

  • Radiation

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