A comparison of the metabolism of cis,cis-, cis,trans/trans,cis- and trans,trans-9,12-octadecadienoic acids in rat liver

Nobuhiro Fukuda, B. Agr Naomi Igari, M. Agr Tetsuhiro Etoh, Toshiro Hidaka, Ikuo Ikeda, Michihiro Sugano

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

The effect of geometrical isomers of 9,12-octadecadienoic (18:2) acid on ketogenesis and lipid secretion was compared in isolated perfused rat liver. The hepatic uptake of 18:2 acid isomers was similar in the cis,cis (cc)-, trans,trans (tt)-and a mixture of cis,trans/trans,cis (ct/tc)-isomers. The trans-isomers in comparison with the cis-counterpart stimulated ketogenesis, while reduced hepatic secretion of triacylglycerol and cholesterol and the concentration of triacylglycerol in the post-perfused liver. This reciprocal response was dependent on the number of trans double bonds. The trans-isomers infused during the 4h-perfusion periods were actively incorporated into hepatic lipids and secreted at the expense of endogenous cc-18:2 acid, although the mixture of the mono-trans isomers as compared to the di-trans isomer incorporated more into liver lipids except for phospholipid. On the other hand, less ct-18:2 was incorporated than tc-18:2 into both hepatic and perfusate lipids. These results indicate that both the position and the number of the trans-double bonds in the 18:2 acid determine the pathways of oxidation and esterification.

Original languageEnglish
Pages (from-to)779-786
Number of pages8
JournalNutrition Research
Volume13
Issue number7
DOIs
Publication statusPublished - 1993 Jul
Externally publishedYes

Keywords

  • Ketone body production
  • Perfused rat liver
  • Trans-fatty acid
  • Triacylglycerol secretion

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

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