Abstract
The clinical efficacy, safety and utility of cefozopran (CZOP), a new eephem antibiotic, were evaluated in chronic respiratory infections in a comparative study versus ceftazidime (CAZ), Each drug was administered by intravenous drip infusion at a dose of 1.0 g (potency), twice daily for 14 days, and the forllowing results were obtained: 1. A total of 264 patients were enrolled in this study. Efficacy rates (“good” or better responses) were 91.0% (101/111) in the CZOP group and 88.3% (106/120) in the CAZ group, with no significant difference between the two groups. 2. Bacteriologically, eradication rates were 91.5% (65/71) in the CZOP group and 85.3% (64/ 75) in the CAZ group, with no significant difference between the two groups. 3. Adverse reactions occurred in 8 of the 122 patients in the CZOP group and in 3 of the 126 patients in the CAZ group. There was no significant difference between the two groups. The incidence of abnormal laboratory findings was 27.7% (33/119) in the CZOP group and 19.8% (25/ 126) in the CAZ group with no significant difference between the two groups. 4. The usefulness rates (“useful” or better evaluations) were 87.6% (99/113) in the CZOP group and 86.0% (104/121) in the CAZ group, with no significant difference between the two groups. No significant differences were observed between the two groups with respect to any of the above parameters. These results indicate that CZOP is useful for the treatment of chronic respiratory tract infections.
Original language | English |
---|---|
Pages (from-to) | 989-1017 |
Number of pages | 29 |
Journal | Chemotherapy |
Volume | 41 |
Issue number | 9 |
DOIs | |
Publication status | Published - 1993 |
Externally published | Yes |
Keywords
- cefozopran
- ceftazidime
- chronic respiratory tract infection
- comparative study
ASJC Scopus subject areas
- Pharmacology (medical)
- Infectious Diseases
- Pharmacology
- Drug Discovery
- Oncology