A comparative study of cefoselis and ceftazidime in chronic respiratory tract infections

Rinzo Soejima, Yoshihito Niki, Osamu Moriya, Masamitu Nakajima, Kenjiro Kikuchi, Yoshinobu Osaki, Hitoshi Nakano, Jun ichi Maruyama, Hideaki Omiya, Tetsuo Shimizu, Toshiaki Fujikane, Hirotaka Hashizume, Yuka Fujita, Tadakatsu Tsuji, Akira Saito, Kazuo Takebe, Mitsuo Masuda, Seiichi Murakami, Hisashi Nakahata, Kazuki KonishiHiroshi Inoue, Kenichi Takeuchi, Masashi Tamura, Toshihiro Nukiwa, Akira Watanabe, Yushi Nakai, Yoshihiro Honda, Shigeo Takizawa, Kenji Yanagise, Mikae Nakamura, Kohya Shiba, Osamu Sakai, Kazuhisa Okada, Atsushi Satio, Mitsuo Sakamoto, Hiroyichi Tanimoto, Tetsuo Okamura, Ayumu Shimiza, Taichi Mochizuki, Kaoru Shimada, Yusuki Sano, Yasuo Arai, Hiroyuki Kobayashi, Susumu Sakayori, Hiroshi Miura, Fumio Matsumoto, Takeo Imai, Nahoko Shindo, Shoichiro Irimajiri, Yasuo Matsuoka, Yasuo Osone, Norio Kikuchi, Masaaki Arakawa, Kouichi Wada, Shigeyuki Hoshino, Akira Iwashima, Fumihide Iwata, Osamu Sekine, Yasutoshi Suzuki, Nobuki Aoki, Atsuhiko Sato, Masatoshi Iwata, Rinko Kita, Masaaki Ida, Yutaka Nakano, Takayoshi Watanabe, Toshihiko Takeuchi, Yasuo Yamada, Atsushi Nakamura, Hideaki Hanaki, Makoto Kawakami, Shinji Takeyama, Ikuji Usami, Hideaki Kuroki, Fumio Miki, Eiro Tsubura, Tomio Masuno, Hitoaki Okamori, Kazuo Nishii, Masaru Nakagawa, Toshihiko Yamaguchi, Yoshihiro Takishita, Hiroyasu Bando, Yoshihiro Suzuki, Nobuhiro Narita, Keiichi Mikasa, Masayoshi Sawaki, Toshiharu Matsushima, Makoto Kimura, Takao Sasaki, Yuji Sugimoto, Ikuo Matsumoto, Masahiko Hiramoto, Kikuo NakanoKikuo, Jiro Takahara, Jiro Fujita, Yasufumi Yamaji, Masaru Kamei, Yoshiro Sawae, Kaoru Okada, Koji Takaki, Hiroyasu Misumi, Kotaro Oizumi, Yoichiro Ichikawa, Seiji Kinoshita, Hozumi Yamada, Yousuke Aoki, Kaimei Nakahara, Michihiro Kawashima, Tsuneo Ishibashi, Masahiro Takamoto, Kohei Hara, Shigeru Kohno, Hironobu Koga, Mitsuo Kaku, Kazunori Tomono, Yasumasa Dotsu, Koichi Watanabe, Rokushi Oka, Hidenori Sugiyama, Shigefumi Maesaki, Hideo Mashimoto, Keizo Matsumoto, Hiroshi Watanabe, Hidefumi Ishikawa, Akemi Ohmori, Masakazu Takasugi, Keiko Tsuchihashi, Hiroaki Mitsushima, Hirofumi Tanaka, Moritoshi Akiyama, Sakamoto Tasaku, Tsuyoshi Nagatake, Nasu Masaru, Tohru Yamazaki, Yoichiro Goto, Atsushi Saito, Fukuhara Hiroshi, Masao Tateyama, Keisuke Sunakawa

Research output: Contribution to journalArticle

Abstract

The clinical efficacy, safety and usefulness of cefoselis (FK037: FK), a new parenteral cephalosporin, were evaluated in in bacterial pneumonia in a comparative study versus ceftazidime (CAZ). Each drug was administered by intravenous drip infusion at a dose of 1.0g (potency), twice daily for 14 days. The following results were obtained. 1. Of the total 186 cases enrolled, 146 cases were evaluated for clinical efficacy and the efficacy rates(—good— and better responses)were 92.3%(72/78)in the FK group and 91.2%(62/68)in the CAZ group. 2. Bacteriological effects (eradication rates) were 100% (21/21) in the FK group and 96.4% (27/28)in the CAZ group. 3. Adverse reactions occurred in 3 of the 90 patients (3.3%) in the FK group and in 3 of the 88 patients(3.4%) in the CAZ group. The incidence of abnormal laboratory findings was 20.0% (18/90) in the FK group and 18.3% (15/82) in the CAZ group. The safety rate(—safe— in overall safety rating) was 78.9%(71/90) in the FK group and 81.7% (67/82) in the CAZ group. 4.Usefulness rates(—useful— and better responses) were 89.7% (70/78) in the FK group and 88.1% (59/67) in the CAZ group. No significant difference was observed between the two groups in any of the above ratings. The results indicate that FK 037 is as useful as ceftazidime for the treatment of bacterial pneumonia.

Original languageEnglish
Pages (from-to)436-450
Number of pages15
JournalJapanese Journal of Chemotherapy
Volume43
Issue number4
DOIs
Publication statusPublished - 1995

Keywords

  • FK 037
  • cefoselis

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'A comparative study of cefoselis and ceftazidime in chronic respiratory tract infections'. Together they form a unique fingerprint.

  • Cite this

    Soejima, R., Niki, Y., Moriya, O., Nakajima, M., Kikuchi, K., Osaki, Y., Nakano, H., Maruyama, J. I., Omiya, H., Shimizu, T., Fujikane, T., Hashizume, H., Fujita, Y., Tsuji, T., Saito, A., Takebe, K., Masuda, M., Murakami, S., Nakahata, H., ... Sunakawa, K. (1995). A comparative study of cefoselis and ceftazidime in chronic respiratory tract infections. Japanese Journal of Chemotherapy, 43(4), 436-450. https://doi.org/10.11250/chemotherapy1995.43.436