A comparative study of cefoselis and ceftazidime in bacterial pneumonia

Rinzo Soejima; Yoshihito Niki; Osamu Moriya; Masamitsu Nakajima; Kenjiro Kikuchi; Yoshinobu Osaki; Hitoshi Nakano; Jun Ichi Maruyama; Hideaki Omiya; Tetsuo Shimizu; Toshiaki Fujikane; Hirotaka Hashizume; Yuka Fujita; Tadakatsu Tsuji; Akira Saito; Kazuo Takebe; Mitsuo Masuda; Seiichi Murakami; Hisashi Nakahata; Kazuki Konishi; Hiroshi Inoue; Kenichi Takeuchi; Masashi Tamura; Toshihiro Nukiwa; Akira Watanabe; Yushi Nakai; Yoshihiro Honda; Shigeo Takizawa; Kenji Yanase; Mikae Nakamura; Kohya Shiba; Osamu Sakai; Kazuhisa Okada; Atsushi Saito; Mitsuo Sakamoto; Hiroichi Tanimoto; Tetsuo Okamura; Ayumu Shimizu; Taichi Mochizuki; Kaoru Shimada; Yasuyuki Sano; Yasuo Arai; Hiroyuki Kobayashi; Susumu Sakayori; Hiroshi Miura; Fumio Matsumoto; Takeo Imai; Nahoko Shindo; Shoichiro Irimajiri; Yasuo Matsuoka; Yasuo Osone; Norio Kikuchi; Masaaki Arakawa; Kouichi Wada; Shigeyuki Hoshino; Akira Iwashima; Fumihide Iwata; Osamu Sekine; Yasutoshi Suzuki; Nobuki Aoki; Atsuhiko Sato; Masatoshi Iwata; Rinko Kita; Masaaki Ida; Yutaka Nakano; Takayoshi Watanabe; Toshihiko Takeuchi; Yasuo Yamada; Atsushi Nakamura; Hidekazu Hanaki; Makoto Kawakami; Shinji Takeyamac; Ikuji Usami; Hideaki Kuroki; Fumio Miki; Eiro Tsubura; Tomio Masuno; Hitoaki Okamori; Kazuo Nishii; Masaru Nakagawa; Toshihiko Yamaguchi; Yoshihiro Takishita; Hiroyasu Bando; Yoshihiro Suzuki; Nobuhiro Narita; Keiichi Mikasa; Masayoshi Sawaki; Toshiharu Matsushima; Makoto Kimura; Takao Sasaki; Yuji Sugimoto; Ikuo Matsumoto; Masahiko Hiramoto; Kikuo Nakano; Jiro Takahara; Jiro Fujita; Yasufumi Yamaji; Masaru Kamei; Yoshiro Sawae

A comparative study of cefoselis and ceftazidime in bacterial pneumonia

Rinzo Soejima, Yoshihito Niki, Osamu Moriya, Masamitsu Nakajima, Kenjiro Kikuchi, Yoshinobu Osaki, Hitoshi Nakano, Jun Ichi Maruyama, Hideaki Omiya, Tetsuo Shimizu, Toshiaki Fujikane, Hirotaka Hashizume, Yuka Fujita, Tadakatsu Tsuji, Akira Saito, Kazuo Takebe, Mitsuo Masuda, Seiichi Murakami, Hisashi Nakahata, Kazuki KonishiHiroshi Inoue, Kenichi Takeuchi, Masashi Tamura, Toshihiro Nukiwa, Akira Watanabe, Yushi Nakai, Yoshihiro Honda, Shigeo Takizawa, Kenji Yanase, Mikae Nakamura, Kohya Shiba, Osamu Sakai, Kazuhisa Okada, Atsushi Saito, Mitsuo Sakamoto, Hiroichi Tanimoto, Tetsuo Okamura, Ayumu Shimizu, Taichi Mochizuki, Kaoru Shimada, Yasuyuki Sano, Yasuo Arai, Hiroyuki Kobayashi, Susumu Sakayori, Hiroshi Miura, Fumio Matsumoto, Takeo Imai, Nahoko Shindo, Shoichiro Irimajiri, Yasuo Matsuoka, Yasuo Osone, Norio Kikuchi, Masaaki Arakawa, Kouichi Wada, Shigeyuki Hoshino, Akira Iwashima, Fumihide Iwata, Osamu Sekine, Yasutoshi Suzuki, Nobuki Aoki, Atsuhiko Sato, Masatoshi Iwata, Rinko Kita, Masaaki Ida, Yutaka Nakano, Takayoshi Watanabe, Toshihiko Takeuchi, Yasuo Yamada, Atsushi Nakamura, Hidekazu Hanaki, Makoto Kawakami, Shinji Takeyamac, Ikuji Usami, Hideaki Kuroki, Fumio Miki, Eiro Tsubura, Tomio Masuno, Hitoaki Okamori, Kazuo Nishii, Masaru Nakagawa, Toshihiko Yamaguchi, Yoshihiro Takishita, Hiroyasu Bando, Yoshihiro Suzuki, Nobuhiro Narita, Keiichi Mikasa, Masayoshi Sawaki, Toshiharu Matsushima, Makoto Kimura, Takao Sasaki, Yuji Sugimoto, Ikuo Matsumoto, Masahiko Hiramoto, Kikuo Nakano, Jiro Takahara, Jiro Fujita, Yasufumi Yamaji, Masaru Kamei, Yoshiro Sawae

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

The clinical efficacy, safety and usefulness of cefoselis (FK 037, CFSL), a new parenteral cephalosporin, were evaluated in bacterial pneumonia in a comparative study with ceftazidime (CAZ). Each drug was administered by intravenous drip infusion at a dose of 1.0 g (potency), twice daily for 14 days. The following results were obtained. 1. Of the total 178 patients enrolled, 138 were evaluated for clinical efficacy and the efficacy rates ('good' and better responses) were 91.9% (68/74) in the CFSL group and 92.2% (59/64) in the CAZ group. 2. Bacteriological effects (eradication rates) were 100% (18/18) in the CFSL group and 96.0% (24/25) in the CAZ group. 3. Adverse reactions occurred in 3 of the 66 patients (3.5%) in the CFSL group and in 3 of the 84 patients (3.6%) in the CAZ group. The incidence of abnormal laboratory findings was 20.9% (18/86) in the CFSL group and 19.0% (15/79) in the CAZ group. The safety rate ('safe' in the overall safety rating) was 77.9% (67/86) in the CFSL group and 81.0% (64/79) in the CAZ group. 4. Usefulness rates ('useful' and better responses) were 89.2% (66/74) in the CFSL group and 87.5% (56/64) in the CAZ group. No significant difference was observed between the two groups in any of the above ratings. The results indicate that cefoselis is as useful as ceftazidime for the treatment of bacterial pneumonia. This paper reports clinical results excluding cases violating Good Clinical Practice (GCP) found after publication of our previous paper in 'Jpn. J. Chemother.' (Vol. 43, No. 4, 1995).

Original language	English
Pages (from-to)	509-526
Number of pages	18
Journal	Japanese Journal of Chemotherapy
Volume	44
Issue number	7
Publication status	Published - 1996

Keywords

FK 037
cefoselis

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

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Soejima, R., Niki, Y., Moriya, O., Nakajima, M., Kikuchi, K., Osaki, Y., Nakano, H., Maruyama, J. I., Omiya, H., Shimizu, T., Fujikane, T., Hashizume, H., Fujita, Y., Tsuji, T., Saito, A., Takebe, K., Masuda, M., Murakami, S., Nakahata, H., ... Sawae, Y. (1996). A comparative study of cefoselis and ceftazidime in bacterial pneumonia. Japanese Journal of Chemotherapy, 44(7), 509-526.

A comparative study of cefoselis and ceftazidime in bacterial pneumonia. / Soejima, Rinzo; Niki, Yoshihito; Moriya, Osamu; Nakajima, Masamitsu; Kikuchi, Kenjiro; Osaki, Yoshinobu; Nakano, Hitoshi; Maruyama, Jun Ichi; Omiya, Hideaki; Shimizu, Tetsuo; Fujikane, Toshiaki; Hashizume, Hirotaka; Fujita, Yuka; Tsuji, Tadakatsu; Saito, Akira; Takebe, Kazuo; Masuda, Mitsuo; Murakami, Seiichi; Nakahata, Hisashi; Konishi, Kazuki; Inoue, Hiroshi; Takeuchi, Kenichi; Tamura, Masashi; Nukiwa, Toshihiro; Watanabe, Akira; Nakai, Yushi; Honda, Yoshihiro; Takizawa, Shigeo; Yanase, Kenji; Nakamura, Mikae; Shiba, Kohya; Sakai, Osamu; Okada, Kazuhisa; Saito, Atsushi; Sakamoto, Mitsuo; Tanimoto, Hiroichi; Okamura, Tetsuo; Shimizu, Ayumu; Mochizuki, Taichi; Shimada, Kaoru; Sano, Yasuyuki; Arai, Yasuo; Kobayashi, Hiroyuki; Sakayori, Susumu; Miura, Hiroshi; Matsumoto, Fumio; Imai, Takeo; Shindo, Nahoko; Irimajiri, Shoichiro; Matsuoka, Yasuo; Osone, Yasuo; Kikuchi, Norio; Arakawa, Masaaki; Wada, Kouichi; Hoshino, Shigeyuki; Iwashima, Akira; Iwata, Fumihide; Sekine, Osamu; Suzuki, Yasutoshi; Aoki, Nobuki; Sato, Atsuhiko; Iwata, Masatoshi; Kita, Rinko; Ida, Masaaki; Nakano, Yutaka; Watanabe, Takayoshi; Takeuchi, Toshihiko; Yamada, Yasuo; Nakamura, Atsushi; Hanaki, Hidekazu; Kawakami, Makoto; Takeyamac, Shinji; Usami, Ikuji; Kuroki, Hideaki; Miki, Fumio; Tsubura, Eiro; Masuno, Tomio; Okamori, Hitoaki; Nishii, Kazuo; Nakagawa, Masaru; Yamaguchi, Toshihiko; Takishita, Yoshihiro; Bando, Hiroyasu; Suzuki, Yoshihiro; Narita, Nobuhiro; Mikasa, Keiichi; Sawaki, Masayoshi; Matsushima, Toshiharu; Kimura, Makoto; Sasaki, Takao; Sugimoto, Yuji; Matsumoto, Ikuo; Hiramoto, Masahiko; Nakano, Kikuo; Takahara, Jiro; Fujita, Jiro; Yamaji, Yasufumi; Kamei, Masaru; Sawae, Yoshiro.

In: Japanese Journal of Chemotherapy, Vol. 44, No. 7, 1996, p. 509-526.

Research output: Contribution to journal › Article › peer-review

Soejima, R, Niki, Y, Moriya, O, Nakajima, M, Kikuchi, K, Osaki, Y, Nakano, H, Maruyama, JI, Omiya, H, Shimizu, T, Fujikane, T, Hashizume, H, Fujita, Y, Tsuji, T, Saito, A, Takebe, K, Masuda, M, Murakami, S, Nakahata, H, Konishi, K, Inoue, H, Takeuchi, K, Tamura, M, Nukiwa, T, Watanabe, A, Nakai, Y, Honda, Y, Takizawa, S, Yanase, K, Nakamura, M, Shiba, K, Sakai, O, Okada, K, Saito, A, Sakamoto, M, Tanimoto, H, Okamura, T, Shimizu, A, Mochizuki, T, Shimada, K, Sano, Y, Arai, Y, Kobayashi, H, Sakayori, S, Miura, H, Matsumoto, F, Imai, T, Shindo, N, Irimajiri, S, Matsuoka, Y, Osone, Y, Kikuchi, N, Arakawa, M, Wada, K, Hoshino, S, Iwashima, A, Iwata, F, Sekine, O, Suzuki, Y, Aoki, N, Sato, A, Iwata, M, Kita, R, Ida, M, Nakano, Y, Watanabe, T, Takeuchi, T, Yamada, Y, Nakamura, A, Hanaki, H, Kawakami, M, Takeyamac, S, Usami, I, Kuroki, H, Miki, F, Tsubura, E, Masuno, T, Okamori, H, Nishii, K, Nakagawa, M, Yamaguchi, T, Takishita, Y, Bando, H, Suzuki, Y, Narita, N, Mikasa, K, Sawaki, M, Matsushima, T, Kimura, M, Sasaki, T, Sugimoto, Y, Matsumoto, I, Hiramoto, M, Nakano, K, Takahara, J, Fujita, J, Yamaji, Y, Kamei, M & Sawae, Y 1996, 'A comparative study of cefoselis and ceftazidime in bacterial pneumonia', Japanese Journal of Chemotherapy, vol. 44, no. 7, pp. 509-526.

Soejima, Rinzo ; Niki, Yoshihito ; Moriya, Osamu ; Nakajima, Masamitsu ; Kikuchi, Kenjiro ; Osaki, Yoshinobu ; Nakano, Hitoshi ; Maruyama, Jun Ichi ; Omiya, Hideaki ; Shimizu, Tetsuo ; Fujikane, Toshiaki ; Hashizume, Hirotaka ; Fujita, Yuka ; Tsuji, Tadakatsu ; Saito, Akira ; Takebe, Kazuo ; Masuda, Mitsuo ; Murakami, Seiichi ; Nakahata, Hisashi ; Konishi, Kazuki ; Inoue, Hiroshi ; Takeuchi, Kenichi ; Tamura, Masashi ; Nukiwa, Toshihiro ; Watanabe, Akira ; Nakai, Yushi ; Honda, Yoshihiro ; Takizawa, Shigeo ; Yanase, Kenji ; Nakamura, Mikae ; Shiba, Kohya ; Sakai, Osamu ; Okada, Kazuhisa ; Saito, Atsushi ; Sakamoto, Mitsuo ; Tanimoto, Hiroichi ; Okamura, Tetsuo ; Shimizu, Ayumu ; Mochizuki, Taichi ; Shimada, Kaoru ; Sano, Yasuyuki ; Arai, Yasuo ; Kobayashi, Hiroyuki ; Sakayori, Susumu ; Miura, Hiroshi ; Matsumoto, Fumio ; Imai, Takeo ; Shindo, Nahoko ; Irimajiri, Shoichiro ; Matsuoka, Yasuo ; Osone, Yasuo ; Kikuchi, Norio ; Arakawa, Masaaki ; Wada, Kouichi ; Hoshino, Shigeyuki ; Iwashima, Akira ; Iwata, Fumihide ; Sekine, Osamu ; Suzuki, Yasutoshi ; Aoki, Nobuki ; Sato, Atsuhiko ; Iwata, Masatoshi ; Kita, Rinko ; Ida, Masaaki ; Nakano, Yutaka ; Watanabe, Takayoshi ; Takeuchi, Toshihiko ; Yamada, Yasuo ; Nakamura, Atsushi ; Hanaki, Hidekazu ; Kawakami, Makoto ; Takeyamac, Shinji ; Usami, Ikuji ; Kuroki, Hideaki ; Miki, Fumio ; Tsubura, Eiro ; Masuno, Tomio ; Okamori, Hitoaki ; Nishii, Kazuo ; Nakagawa, Masaru ; Yamaguchi, Toshihiko ; Takishita, Yoshihiro ; Bando, Hiroyasu ; Suzuki, Yoshihiro ; Narita, Nobuhiro ; Mikasa, Keiichi ; Sawaki, Masayoshi ; Matsushima, Toshiharu ; Kimura, Makoto ; Sasaki, Takao ; Sugimoto, Yuji ; Matsumoto, Ikuo ; Hiramoto, Masahiko ; Nakano, Kikuo ; Takahara, Jiro ; Fujita, Jiro ; Yamaji, Yasufumi ; Kamei, Masaru ; Sawae, Yoshiro. / A comparative study of cefoselis and ceftazidime in bacterial pneumonia. In: Japanese Journal of Chemotherapy. 1996 ; Vol. 44, No. 7. pp. 509-526.

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abstract = "The clinical efficacy, safety and usefulness of cefoselis (FK 037, CFSL), a new parenteral cephalosporin, were evaluated in bacterial pneumonia in a comparative study with ceftazidime (CAZ). Each drug was administered by intravenous drip infusion at a dose of 1.0 g (potency), twice daily for 14 days. The following results were obtained. 1. Of the total 178 patients enrolled, 138 were evaluated for clinical efficacy and the efficacy rates ('good' and better responses) were 91.9% (68/74) in the CFSL group and 92.2% (59/64) in the CAZ group. 2. Bacteriological effects (eradication rates) were 100% (18/18) in the CFSL group and 96.0% (24/25) in the CAZ group. 3. Adverse reactions occurred in 3 of the 66 patients (3.5%) in the CFSL group and in 3 of the 84 patients (3.6%) in the CAZ group. The incidence of abnormal laboratory findings was 20.9% (18/86) in the CFSL group and 19.0% (15/79) in the CAZ group. The safety rate ('safe' in the overall safety rating) was 77.9% (67/86) in the CFSL group and 81.0% (64/79) in the CAZ group. 4. Usefulness rates ('useful' and better responses) were 89.2% (66/74) in the CFSL group and 87.5% (56/64) in the CAZ group. No significant difference was observed between the two groups in any of the above ratings. The results indicate that cefoselis is as useful as ceftazidime for the treatment of bacterial pneumonia. This paper reports clinical results excluding cases violating Good Clinical Practice (GCP) found after publication of our previous paper in 'Jpn. J. Chemother.' (Vol. 43, No. 4, 1995).",

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T1 - A comparative study of cefoselis and ceftazidime in bacterial pneumonia

AU - Soejima, Rinzo

AU - Niki, Yoshihito

AU - Moriya, Osamu

AU - Nakajima, Masamitsu

AU - Kikuchi, Kenjiro

AU - Osaki, Yoshinobu

AU - Nakano, Hitoshi

AU - Maruyama, Jun Ichi

AU - Omiya, Hideaki

AU - Shimizu, Tetsuo

AU - Fujikane, Toshiaki

AU - Hashizume, Hirotaka

AU - Fujita, Yuka

AU - Tsuji, Tadakatsu

AU - Saito, Akira

AU - Takebe, Kazuo

AU - Masuda, Mitsuo

AU - Murakami, Seiichi

AU - Nakahata, Hisashi

AU - Konishi, Kazuki

AU - Inoue, Hiroshi

AU - Takeuchi, Kenichi

AU - Tamura, Masashi

AU - Nukiwa, Toshihiro

AU - Watanabe, Akira

AU - Nakai, Yushi

AU - Honda, Yoshihiro

AU - Takizawa, Shigeo

AU - Yanase, Kenji

AU - Nakamura, Mikae

AU - Shiba, Kohya

AU - Sakai, Osamu

AU - Okada, Kazuhisa

AU - Saito, Atsushi

AU - Sakamoto, Mitsuo

AU - Tanimoto, Hiroichi

AU - Okamura, Tetsuo

AU - Shimizu, Ayumu

AU - Mochizuki, Taichi

AU - Shimada, Kaoru

AU - Sano, Yasuyuki

AU - Arai, Yasuo

AU - Kobayashi, Hiroyuki

AU - Sakayori, Susumu

AU - Miura, Hiroshi

AU - Matsumoto, Fumio

AU - Imai, Takeo

AU - Shindo, Nahoko

AU - Irimajiri, Shoichiro

AU - Matsuoka, Yasuo

AU - Osone, Yasuo

AU - Kikuchi, Norio

AU - Arakawa, Masaaki

AU - Wada, Kouichi

AU - Hoshino, Shigeyuki

AU - Iwashima, Akira

AU - Iwata, Fumihide

AU - Sekine, Osamu

AU - Suzuki, Yasutoshi

AU - Aoki, Nobuki

AU - Sato, Atsuhiko

AU - Iwata, Masatoshi

AU - Kita, Rinko

AU - Ida, Masaaki

AU - Nakano, Yutaka

AU - Watanabe, Takayoshi

AU - Takeuchi, Toshihiko

AU - Yamada, Yasuo

AU - Nakamura, Atsushi

AU - Hanaki, Hidekazu

AU - Kawakami, Makoto

AU - Takeyamac, Shinji

AU - Usami, Ikuji

AU - Kuroki, Hideaki

AU - Miki, Fumio

AU - Tsubura, Eiro

AU - Masuno, Tomio

AU - Okamori, Hitoaki

AU - Nishii, Kazuo

AU - Nakagawa, Masaru

AU - Yamaguchi, Toshihiko

AU - Takishita, Yoshihiro

AU - Bando, Hiroyasu

AU - Suzuki, Yoshihiro

AU - Narita, Nobuhiro

AU - Mikasa, Keiichi

AU - Sawaki, Masayoshi

AU - Matsushima, Toshiharu

AU - Kimura, Makoto

AU - Sasaki, Takao

AU - Sugimoto, Yuji

AU - Matsumoto, Ikuo

AU - Hiramoto, Masahiko

AU - Nakano, Kikuo

AU - Takahara, Jiro

AU - Fujita, Jiro

AU - Yamaji, Yasufumi

AU - Kamei, Masaru

AU - Sawae, Yoshiro

PY - 1996

Y1 - 1996

N2 - The clinical efficacy, safety and usefulness of cefoselis (FK 037, CFSL), a new parenteral cephalosporin, were evaluated in bacterial pneumonia in a comparative study with ceftazidime (CAZ). Each drug was administered by intravenous drip infusion at a dose of 1.0 g (potency), twice daily for 14 days. The following results were obtained. 1. Of the total 178 patients enrolled, 138 were evaluated for clinical efficacy and the efficacy rates ('good' and better responses) were 91.9% (68/74) in the CFSL group and 92.2% (59/64) in the CAZ group. 2. Bacteriological effects (eradication rates) were 100% (18/18) in the CFSL group and 96.0% (24/25) in the CAZ group. 3. Adverse reactions occurred in 3 of the 66 patients (3.5%) in the CFSL group and in 3 of the 84 patients (3.6%) in the CAZ group. The incidence of abnormal laboratory findings was 20.9% (18/86) in the CFSL group and 19.0% (15/79) in the CAZ group. The safety rate ('safe' in the overall safety rating) was 77.9% (67/86) in the CFSL group and 81.0% (64/79) in the CAZ group. 4. Usefulness rates ('useful' and better responses) were 89.2% (66/74) in the CFSL group and 87.5% (56/64) in the CAZ group. No significant difference was observed between the two groups in any of the above ratings. The results indicate that cefoselis is as useful as ceftazidime for the treatment of bacterial pneumonia. This paper reports clinical results excluding cases violating Good Clinical Practice (GCP) found after publication of our previous paper in 'Jpn. J. Chemother.' (Vol. 43, No. 4, 1995).

AB - The clinical efficacy, safety and usefulness of cefoselis (FK 037, CFSL), a new parenteral cephalosporin, were evaluated in bacterial pneumonia in a comparative study with ceftazidime (CAZ). Each drug was administered by intravenous drip infusion at a dose of 1.0 g (potency), twice daily for 14 days. The following results were obtained. 1. Of the total 178 patients enrolled, 138 were evaluated for clinical efficacy and the efficacy rates ('good' and better responses) were 91.9% (68/74) in the CFSL group and 92.2% (59/64) in the CAZ group. 2. Bacteriological effects (eradication rates) were 100% (18/18) in the CFSL group and 96.0% (24/25) in the CAZ group. 3. Adverse reactions occurred in 3 of the 66 patients (3.5%) in the CFSL group and in 3 of the 84 patients (3.6%) in the CAZ group. The incidence of abnormal laboratory findings was 20.9% (18/86) in the CFSL group and 19.0% (15/79) in the CAZ group. The safety rate ('safe' in the overall safety rating) was 77.9% (67/86) in the CFSL group and 81.0% (64/79) in the CAZ group. 4. Usefulness rates ('useful' and better responses) were 89.2% (66/74) in the CFSL group and 87.5% (56/64) in the CAZ group. No significant difference was observed between the two groups in any of the above ratings. The results indicate that cefoselis is as useful as ceftazidime for the treatment of bacterial pneumonia. This paper reports clinical results excluding cases violating Good Clinical Practice (GCP) found after publication of our previous paper in 'Jpn. J. Chemother.' (Vol. 43, No. 4, 1995).

KW - FK 037

KW - cefoselis

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UR - http://www.scopus.com/inward/citedby.url?scp=0029786986&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0029786986

VL - 44

SP - 509

EP - 526

JO - Japanese Journal of Chemotherapy

JF - Japanese Journal of Chemotherapy

SN - 1340-7007

IS - 7

ER -