Abstract
We conducted a comparative double-blind study of S-1108, a new ester-type oral cephem antibiotic, and cefteram pivoxil (CFTM-PI) to evaluate the efficacy, safety and usefulness of these drugs in the treatment of chronic respiratory tract infections excluding diffuse panbroncholitis. S-1108 was given orally at a daily dose of 450 mg, and CFTM-PI at a daily dose of 600 mg three times daily for 14 days. The following results were obtained. 1) Of the total 171 patients (86 in the S-1108 group, 85 in the CFTM-PI group), 157 patients (81 in the S-1108 group, 76 in the CFTM-PI group) were evaluated for efficacy. No significant difference was noted between the two drug groups with respect to the percent excluded or background factors of patients. 2) The clinical efficacy rate were 80.2%(65/81 patients) in the S-1108 group, and 78.9%(60/76 patients) in the CFTM-PI group, showing no significant differences between the two groups. 3) Bacteriologically, the elimination rates of causative organisms were 60.5%(23/38 patients) in the S-1108 group and 65.9%(27/41 patients) in the CFTM-PI group, with no significant differences. 4) Side effects were observed in 6.9%(5/83) of patients in the S-1108 group and 6.4%(5/78) of patients in the CFTM-PI group. Abnormal changes in laboratory findings were observed in 13.9%(11/79) of patients in the S-1108 group and 13.9%(10/72) of patients in the CFTM-PI group. There were no significant differences in incidence between the two groups. None of the side effects were severe. 5) The utility rates (very satisfactory and satisfactory) were 77.1%(64/83 patients) in the S-1108 group and 77.6%(59/76 patients) in the CFTM-PI group, with no significant differences between the two groups. The above results indicate that S-1108 at a daily dose of 450 mg is as useful as CFTM-PI at a daily dose of 600 mg in the treatment of chronic respiratory tract infections.
Original language | English |
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Pages (from-to) | 476-503 |
Number of pages | 28 |
Journal | Chemotherapy |
Volume | 42 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1994 |
Externally published | Yes |
Keywords
- S-1108
- cefteram pivoxil
- chronic respiratory infection
- double blind study
ASJC Scopus subject areas
- Pharmacology (medical)
- Infectious Diseases
- Pharmacology
- Drug Discovery
- Oncology