A Combinatorial Synthesis of a Macrosphelide Library Utilizing a Palladium-Catalyzed Carbonylation on a Polymer Support

Takashi Takahashi, Shin Ichi Kusaka, Takayuki Doi, Toshiaki Sunazuka, Satoshi Omura

Research output: Contribution to journalArticlepeer-review

93 Citations (Scopus)

Abstract

Supported total synthesis: The combinatorial synthesis of a 122-membered macrosphelide library including macrosphelides A, C, E, and F (see picture) has been achieved based on a unique strategy for a three-component coupling utilizing a palladium-catalyzed chemoselective carbonylation and an unprecedented macrolactonization on a polymer support.

Original languageEnglish
Pages (from-to)5230-5234
Number of pages5
JournalAngewandte Chemie - International Edition
Volume42
Issue number42
DOIs
Publication statusPublished - 2003 Nov 3
Externally publishedYes

Keywords

  • Chemoselectivity
  • Combinatorial chemistry
  • Macrosphelides
  • Palladium
  • Solid-phase synthesis

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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