A Cluster Randomized Controlled Trial of Nonpharmacological Interventions for Old-Old Subjects with a Clinical Dementia Rating of 0.5: The Kurihara Project

Masahiro Nakatsuka, Kei Nakamura, Ryo Hamanosono, Yumi Takahashi, Mari Kasai, Yuko Sato, Teiko Suto, Ryoichi Nagatomi, Kenichi Meguro

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Background: Evidence as to the benefits of nonpharmacological interventions for the boundary state between normal aging and dementia [mild cognitive impairment or a Clinical Dementia Rating (CDR) of 0.5] remains weak due to a lack of positive controls. Aims: To directly compare the effects of cognitive interventions (CI), physical activities (PA) and a group reminiscence approach (GRA), we conducted a pilot study on the basis of a cluster randomized controlled trial design. Method: A total of 127 participants aged >74 years with a CDR of 0.5 were cluster randomized into three groups for CI, PA and GRA. The intervention lasted 12 weeks and consisted of weekly group sessions and home assignments. Mini-Mental State Examination (MMSE), Trail Making Test part A (TMT-A), word fluency (WF), 6-meter walk time and Quality of Life (QOL) Face Scale scores were evaluated as primary outcomes. Results: Methodology-related benefits of CI and PA were found for MMSE scores and walk time, respectively. TMT-A, WF and QOL Face Scale scores improved irrespective of the methodologies used. Conclusions: Our findings suggest that CI and PA may be beneficial to cognitive and physical abilities, respectively. Executive functions and QOL may improve irrespective of the intervention methodologies used.

Original languageEnglish
Pages (from-to)221-232
Number of pages12
JournalDementia and Geriatric Cognitive Disorders Extra
Volume5
Issue number2
DOIs
Publication statusPublished - 2015 May 30

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Psychiatry and Mental health

Fingerprint

Dive into the research topics of 'A Cluster Randomized Controlled Trial of Nonpharmacological Interventions for Old-Old Subjects with a Clinical Dementia Rating of 0.5: The Kurihara Project'. Together they form a unique fingerprint.

Cite this