A change in the sensitivity of elongation factor G to oxidation protects photosystem II from photoinhibition in Synechocystis sp. PCC 6803

Kayoko Ejima, Tomoko Kawaharada, Shuhei Inoue, Kouji Kojima, Yoshitaka Nishiyama

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

The repair of photosystem II (PSII) after photodamage is particularly sensitive to oxidative stress and inhibition of such repair is associated with the oxidation of specific cysteine residues in elongation factor G (EF-G), a key translation factor, in the cyanobacterium Synechocystis sp. PCC 6803. Expression of mutated EF-G with a target cysteine residue replaced by serine in Synechocystis resulted in the protection of PSII from photoinhibition. This protection was attributable to the enhanced repair of PSII via acceleration of the synthesis of the D1 protein, which might have been due to reduced sensitivity of protein synthesis to oxidative stress.

Original languageEnglish
Pages (from-to)778-783
Number of pages6
JournalFEBS Letters
Volume586
Issue number6
DOIs
Publication statusPublished - 2012 Mar 23

Keywords

  • Elongation factor G
  • Oxidative stress
  • Photoinhibition
  • Photosystem II
  • Protein synthesis
  • Repair

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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