A Cell-Targeted Non-Cytotoxic Fluorescent Nanogel Thermometer Created with an Imidazolium-Containing Cationic Radical Initiator

Seiichi Uchiyama, Toshikazu Tsuji, Kyoko Kawamoto, Kentaro Okano, Eiko Fukatsu, Takahiro Noro, Kumiko Ikado, Sayuri Yamada, Yuka Shibata, Teruyuki Hayashi, Noriko Inada, Masaru Kato, Hideki Koizumi, Hidetoshi Tokuyama

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

A cationic fluorescent nanogel thermometer based on thermo-responsive N-isopropylacrylamide and environment-sensitive benzothiadiazole was developed with a new azo compound bearing imidazolium rings as the first cationic radical initiator. This cationic fluorescent nanogel thermometer showed an excellent ability to enter live mammalian cells in a short incubation period (10 min), a high sensitivity to temperature variations in live cells (temperature resolution of 0.02–0.84 °C in the range 20–40 °C), and remarkable non-cytotoxicity, which permitted ordinary cell proliferation and even differentiation of primary cultured cells.

Original languageEnglish
Pages (from-to)5413-5417
Number of pages5
JournalAngewandte Chemie - International Edition
Volume57
Issue number19
DOIs
Publication statusPublished - 2018 May 4

Keywords

  • fluorescence spectroscopy
  • fluorescent probes
  • imaging agents
  • nanoparticles
  • sensors

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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