A Cell-Targeted Non-Cytotoxic Fluorescent Nanogel Thermometer Created with an Imidazolium-Containing Cationic Radical Initiator

Seiichi Uchiyama; Toshikazu Tsuji; Kyoko Kawamoto; Kentaro Okano; Eiko Fukatsu; Takahiro Noro; Kumiko Ikado; Sayuri Yamada; Yuka Shibata; Teruyuki Hayashi; Noriko Inada; Masaru Kato; Hideki Koizumi; Hidetoshi Tokuyama

doi:10.1002/anie.201801495

A Cell-Targeted Non-Cytotoxic Fluorescent Nanogel Thermometer Created with an Imidazolium-Containing Cationic Radical Initiator

Seiichi Uchiyama, Toshikazu Tsuji, Kyoko Kawamoto, Kentaro Okano, Eiko Fukatsu, Takahiro Noro, Kumiko Ikado, Sayuri Yamada, Yuka Shibata, Teruyuki Hayashi, Noriko Inada, Masaru Kato, Hideki Koizumi, Hidetoshi Tokuyama

PHA - Molecular Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

A cationic fluorescent nanogel thermometer based on thermo-responsive N-isopropylacrylamide and environment-sensitive benzothiadiazole was developed with a new azo compound bearing imidazolium rings as the first cationic radical initiator. This cationic fluorescent nanogel thermometer showed an excellent ability to enter live mammalian cells in a short incubation period (10 min), a high sensitivity to temperature variations in live cells (temperature resolution of 0.02–0.84 °C in the range 20–40 °C), and remarkable non-cytotoxicity, which permitted ordinary cell proliferation and even differentiation of primary cultured cells.

Original language	English
Pages (from-to)	5413-5417
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	57
Issue number	19
DOIs	https://doi.org/10.1002/anie.201801495
Publication status	Published - 2018 May 4

Keywords

fluorescence spectroscopy
fluorescent probes
imaging agents
nanoparticles
sensors

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.201801495

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Uchiyama, S., Tsuji, T., Kawamoto, K., Okano, K., Fukatsu, E., Noro, T., Ikado, K., Yamada, S., Shibata, Y., Hayashi, T., Inada, N., Kato, M., Koizumi, H., & Tokuyama, H. (2018). A Cell-Targeted Non-Cytotoxic Fluorescent Nanogel Thermometer Created with an Imidazolium-Containing Cationic Radical Initiator. Angewandte Chemie - International Edition, 57(19), 5413-5417. https://doi.org/10.1002/anie.201801495

A Cell-Targeted Non-Cytotoxic Fluorescent Nanogel Thermometer Created with an Imidazolium-Containing Cationic Radical Initiator. / Uchiyama, Seiichi; Tsuji, Toshikazu; Kawamoto, Kyoko; Okano, Kentaro; Fukatsu, Eiko; Noro, Takahiro; Ikado, Kumiko; Yamada, Sayuri; Shibata, Yuka; Hayashi, Teruyuki; Inada, Noriko; Kato, Masaru; Koizumi, Hideki; Tokuyama, Hidetoshi.

In: Angewandte Chemie - International Edition, Vol. 57, No. 19, 04.05.2018, p. 5413-5417.

Research output: Contribution to journal › Article › peer-review

Uchiyama, S, Tsuji, T, Kawamoto, K, Okano, K, Fukatsu, E, Noro, T, Ikado, K, Yamada, S, Shibata, Y, Hayashi, T, Inada, N, Kato, M, Koizumi, H & Tokuyama, H 2018, 'A Cell-Targeted Non-Cytotoxic Fluorescent Nanogel Thermometer Created with an Imidazolium-Containing Cationic Radical Initiator', Angewandte Chemie - International Edition, vol. 57, no. 19, pp. 5413-5417. https://doi.org/10.1002/anie.201801495

Uchiyama, Seiichi ; Tsuji, Toshikazu ; Kawamoto, Kyoko ; Okano, Kentaro ; Fukatsu, Eiko ; Noro, Takahiro ; Ikado, Kumiko ; Yamada, Sayuri ; Shibata, Yuka ; Hayashi, Teruyuki ; Inada, Noriko ; Kato, Masaru ; Koizumi, Hideki ; Tokuyama, Hidetoshi. / A Cell-Targeted Non-Cytotoxic Fluorescent Nanogel Thermometer Created with an Imidazolium-Containing Cationic Radical Initiator. In: Angewandte Chemie - International Edition. 2018 ; Vol. 57, No. 19. pp. 5413-5417.

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