A case with local recurrence of rectal cancer that responded to S-1 and PSK with long-term complete response

Ken Ichi Takahashi, Tetsuya Kakita, Yuji Funayama, Hiromi Tokumura, Takashi Toshima, Shoji Fukuyama, Hiroaki Musya, Naoki Matsumura, Hiroyuki Sasaki, Akihiro Yasumoto

Research output: Contribution to journalArticle

Abstract

The patient was a 65-year-old male, who underwent low anterior resection for rectal cancer. The pathological diagnosis showed mucinous adenocarcinoma, pSS, and pNO. He complained of diarrhea and melena 4 months after the surgery. Abdominal computed tomography and colonofiberscopy showed a local recurrence of rectal cancer. Because the tumor was diagnosed as unresectable, combined chemotherapy of S-1 ( 100 mg/day, per os, 4 weeks of treatment and 2 weeks of rest) and PSK (3 g/day, per os, the same schedule as S-1) was started. After the 2 courses of chemotherapy, computed tomography and colonofiberscopy showed a complete disappearance of the tumor. The chemotherapy was continued until the 9th course and then stopped. Five years and 4 months since the induction of a complete response, the patient is still alive without disease recurrence. Combined chemotherapy of S-1 and PSK may be one of useful choices for recurrent colorectal cancer.

Original languageEnglish
Pages (from-to)2199-2201
Number of pages3
JournalJapanese Journal of Cancer and Chemotherapy
Volume37
Issue number11
Publication statusPublished - 2010 Nov 6

Keywords

  • PSK
  • Rectal cancer
  • S-1

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Takahashi, K. I., Kakita, T., Funayama, Y., Tokumura, H., Toshima, T., Fukuyama, S., Musya, H., Matsumura, N., Sasaki, H., & Yasumoto, A. (2010). A case with local recurrence of rectal cancer that responded to S-1 and PSK with long-term complete response. Japanese Journal of Cancer and Chemotherapy, 37(11), 2199-2201.