A case with anti-galactocerebroside antibody-positive Mycoplasma pneumoniae meningoencephalitis presenting secondary hypersomnia

Naoto Sugeno, Norihiko Kawaguchi, Takafumi Hasegawa, Takashi Kuroda, Ichiro Nakashima, Takashi Kanbayashi, Susumu Kusunoki, Masashi Aoki

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Galactocerebroside (Gal-C) is a major myelin component in the central nervous system. The anti-Gal-C antibody induced by mycoplasma infection may therefore be involved in the pathogenic mechanisms of mycoplasmaassociated encephalitis. Here we report an adult case of mycoplasma encephalitis developing excessive daytime sleepiness. Brain MRI suggested that hypothalamic involvement was compatible with hypersomnia. This finding was corroborated by decreased hypocretin-1 in cerebrospinal fluid (CSF) and the manifestation of diabetes insipidus. Screening for anti-glycolipid antibody profiles showed the selective increase of serum anti-Gal-C antibody. After treatment with minocyclin, the patient's daytime sleepiness was markedly improved and the CSF hypocretin-1 level became almost normal, as well. It is known that CSF hypocretin-1 is decreased in Guillain-Barré syndrome mediated by antiglycolipid antibody, suggesting a possible mechanistic link between anti-glycolipid antibodies and hypothalamic involvement. The present case further emphasizes the broad spectrum of neurological complications after mycoplasma infection.

Original languageEnglish
Pages (from-to)1473-1476
Number of pages4
JournalNeurological Sciences
Volume33
Issue number6
DOIs
Publication statusPublished - 2012 Mar 23

Keywords

  • Anti-glycolipid antibody
  • Hypersomnia
  • Hypocretin-1
  • Mycoplasma pneumoniae

ASJC Scopus subject areas

  • Dermatology
  • Clinical Neurology
  • Psychiatry and Mental health

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