A case of small-cell lung carcinoma with EGFR gene mutation

Sodai Narumil, Akira Inoue, Taizo Shibahara, Ryotaro Igusa, Tomohiro Sakakibaral, Toshihiro Nukiwa

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Background. There are few reports of small-cell lung carcinoma (SCLC) with epidermal growth factor receptor (EGFR) gene mutation and the optimal treatment with EGFR-tyrosine kinase inhibitor (EGFR-TKI) for such patients has not yet been established. Case. A 74-year-old woman with dyspnea was referred to our hospital. A chest X-ray showed left pleural effusion and the mediastinum had shifted to the right. A chest CT image after drainage of her pleural effusion revealed a mass in the left lower lobe with destruction of the spine and ribs, and multiple other lesions (cT4N2M1b). The cytological diagnosis of SCLC was confirmed from pleural effusion specimens. Since SCLC is uncommon in non-smoking patients, we performed screening for EGFR mutations which revealed the presence of an exon 18 replacement mutation (G719C). Although first-line chemotherapy with carboplatin and etoposide was initially effective, her general condition worsened due to disease progression. Gefitinib was tried as a second-line therapy, but it was ineffective. Subsequent chemotherapy with amrubicin was also ineffective and the patient died. Conclusion. We encountered a case of SCLC with EGFR gene mutation in a non-smoker. The efficacy of EGFR-TKI for EGFR-mutated SCLC should be investigated further.

Original languageEnglish
Pages (from-to)798-802
Number of pages5
JournalJapanese Journal of Lung Cancer
Volume51
Issue number7
DOIs
Publication statusPublished - 2011 Dec

Keywords

  • Epidermal growth factor receptor gene mutation
  • Epidermal growth factor receptor tyrosine kinase inhibitor
  • Gefitinib
  • Small-cell lung carcinoma

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine

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