A Case of small-bowel mesenteric desmoid tumor arising during hepatic gastrointestinal stromal tumor metastases treated using imatinib mesylate

Toshinori Ando, Koh Miura, Takeshi Naito, Hitoshi Ogawa, Nobuki Yazaki, Sho Haneda, Chikashi Shibata, Iwao Sasaki, Fumiyoshi Fujishima, Kazuyuki Ishida

Research output: Contribution to journalArticlepeer-review

Abstract

A 66-year old man undergoing partial ileal resection for gastrointestinal stromal tumor (GIST) was diagnosed with multiple liver metastases seven months later. Imatinib mesylate administration was initiated, stabilizing tumors 1.5 years. After he reported abdominal pain, computed tomography (CT) showed an intestinally obstructive tumor. Laparotomy for suspected GIST recurrence radiologically showed an 8cm tumor in the ileal mesentery 210cm distal to the ligament of Treitz and 15cm proximal to the ileal anastomosis. After surgical resection, tumor cells were microscopically diagnosed as differentiated spindle fibroblasts with abundant collagen fibers but without karyomitosis. Immunohistochemically, cells were negative for c-kit, CD34, and S-100 but positive for β-catenin with nuclear translocalization, yielding a pathological diagnosis of mesenteric desmoid tumor. No desmoid tumors have been reported to develop during imatinib mesylate chemotherapy, and it was difficult to differentially diagnose these tumors preoperatively.

Original languageEnglish
Pages (from-to)288-294
Number of pages7
JournalJapanese Journal of Gastroenterological Surgery
Volume44
Issue number3
DOIs
Publication statusPublished - 2011

Keywords

  • Desmoid tumor
  • Gastrointestinal stromal tumor
  • Imatinib mesylate

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology

Fingerprint

Dive into the research topics of 'A Case of small-bowel mesenteric desmoid tumor arising during hepatic gastrointestinal stromal tumor metastases treated using imatinib mesylate'. Together they form a unique fingerprint.

Cite this