A Case of Slowly Progressive Type 1 Diabetes with Insulin Independence Maintained for 10 Years with α-glucosidase Inhibitor Monotherapy

Yuichiro Munakata, Tetsuya Yamada, Kazuma Takahashi, Sohei Tsukita, Kei Takahashi, Shojiro Sawada, Junta Imai, Yasushi Ishigaki, Yoshitomo Oka, Hideki Katagiri

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Slowly Progressive Type 1 Diabetes (SPT1D) is characterized by the absence of insulin dependence at the onset of diabetes and persistent detection of islet cell autoantibodies. These patients with high titers of glutamic acid decarboxylase autoantibodies (GADA) are known to progress to insulin dependence within several years. Low-dose insulin injections have been reported to prevent or delay the decline of insulin secretion in SPT1D patients. We experienced the case of an SPT1D patient with preserved endogenous insulin secretion and good glycemic control achieved with α-glucosidase inhibitor (α-GI) treatment alone for 10 years despite having continuously elevated GADA titers. The details of this case suggest that α-GI treatment might have preventive effects on SPT1D progression.

Original languageEnglish
Pages (from-to)3391-3394
Number of pages4
JournalInternal Medicine
Volume51
Issue number24
DOIs
Publication statusPublished - 2012 Jan 1

Keywords

  • Glutamic acid decarboxylase auto-antibodies
  • Slowly progressive type 1 diabetes
  • α-glucosidase inhibitor

ASJC Scopus subject areas

  • Internal Medicine

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