TY - JOUR
T1 - A case of severe esophageal intramural pseudodiverticulosis whose symptoms were ameliorated by oral administration of anti-fungal medicine
AU - Chiba, Takashi
AU - Iijima, Katsunori
AU - Koike, Tomoyuki
AU - Uno, Kaname
AU - Asano, Naoki
AU - Shimosegawa, Tooru
PY - 2012/1
Y1 - 2012/1
N2 - Esophageal intramural pseudodiverticulosis (EIPD) is a rare disease of unknown etiology that displays multiple pseudodiverticula radiologically, leading to benign esophageal stricture. Dysphagia, which sometimes slowly progresses, is the main symptom in the majority of cases. We here report a 59-year-old male EIPD patient who suffered from severe dysphagia. Radiography and endoscopy of this patient disclosed a severe constriction in the upper thoracic esophagus. Although we tried several endoscopic procedures including frequent endoscopic balloon dilatation (EBD), the effect was very limited and his dysphagia relapsed shortly after the treatments. During the procedures, we noticed some white, thick, creamy liquid emerging from the orifices of EIPD, and PAS staining of biopsy specimens revealed infection with Candida albicans. Hence, the patient was given anti-fungal medicine in addition to EBD. The additional treatment with anti-fungal medicine dramatically improved his symptoms and the esophageal constriction. This case suggests that anti-fungal treatment is an effective first-line therapy even against a severe form of esophageal constriction in EIPD.
AB - Esophageal intramural pseudodiverticulosis (EIPD) is a rare disease of unknown etiology that displays multiple pseudodiverticula radiologically, leading to benign esophageal stricture. Dysphagia, which sometimes slowly progresses, is the main symptom in the majority of cases. We here report a 59-year-old male EIPD patient who suffered from severe dysphagia. Radiography and endoscopy of this patient disclosed a severe constriction in the upper thoracic esophagus. Although we tried several endoscopic procedures including frequent endoscopic balloon dilatation (EBD), the effect was very limited and his dysphagia relapsed shortly after the treatments. During the procedures, we noticed some white, thick, creamy liquid emerging from the orifices of EIPD, and PAS staining of biopsy specimens revealed infection with Candida albicans. Hence, the patient was given anti-fungal medicine in addition to EBD. The additional treatment with anti-fungal medicine dramatically improved his symptoms and the esophageal constriction. This case suggests that anti-fungal treatment is an effective first-line therapy even against a severe form of esophageal constriction in EIPD.
KW - Anti-fungal therapy
KW - Candida albicans
KW - Endoscopic balloon dilatation
KW - Esophageal intramural pseudodiverticulosis
UR - http://www.scopus.com/inward/record.url?scp=84860755609&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84860755609&partnerID=8YFLogxK
U2 - 10.1159/000336846
DO - 10.1159/000336846
M3 - Article
C2 - 22619654
AN - SCOPUS:84860755609
VL - 6
SP - 103
EP - 110
JO - Case Reports in Gastroenterology
JF - Case Reports in Gastroenterology
SN - 1662-0631
IS - 1
ER -