A case of severe esophageal intramural pseudodiverticulosis whose symptoms were ameliorated by oral administration of anti-fungal medicine

Takashi Chiba, Katsunori Iijima, Tomoyuki Koike, Kaname Uno, Naoki Asano, Tooru Shimosegawa

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Esophageal intramural pseudodiverticulosis (EIPD) is a rare disease of unknown etiology that displays multiple pseudodiverticula radiologically, leading to benign esophageal stricture. Dysphagia, which sometimes slowly progresses, is the main symptom in the majority of cases. We here report a 59-year-old male EIPD patient who suffered from severe dysphagia. Radiography and endoscopy of this patient disclosed a severe constriction in the upper thoracic esophagus. Although we tried several endoscopic procedures including frequent endoscopic balloon dilatation (EBD), the effect was very limited and his dysphagia relapsed shortly after the treatments. During the procedures, we noticed some white, thick, creamy liquid emerging from the orifices of EIPD, and PAS staining of biopsy specimens revealed infection with Candida albicans. Hence, the patient was given anti-fungal medicine in addition to EBD. The additional treatment with anti-fungal medicine dramatically improved his symptoms and the esophageal constriction. This case suggests that anti-fungal treatment is an effective first-line therapy even against a severe form of esophageal constriction in EIPD.

Original languageEnglish
Pages (from-to)103-110
Number of pages8
JournalCase Reports in Gastroenterology
Volume6
Issue number1
DOIs
Publication statusPublished - 2012 Jan

Keywords

  • Anti-fungal therapy
  • Candida albicans
  • Endoscopic balloon dilatation
  • Esophageal intramural pseudodiverticulosis

ASJC Scopus subject areas

  • Gastroenterology

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