A case of renin-producing adrenocortical cancer

Kayo Yamanaka, Makoto Iitaka, Munemichi Inaba, Toshisuke Morita, Hironobu Sasano, Shigehiro Katayama

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Here we report a case of a renin-producing adrenocortical carcinoma. A 57-year-old woman was referred to our hospital complaining of thirst and generalized muscle weakness. She was diagnosed as being hypertensive and diabetic with associated hypokalemia and she had a hard elastic mass with a diameter of 10 cm on the left side of her neck. An abdominal computed tomography scan revealed a suprarenal mass on the left side (8.5 x 8 x 6.5 cm). Endocrinological examination demonstrated a marked elevation in the patient's serum glucocorticoid and sex steroid hormones as well as plasma renin activity. Histological examination of a sample taken from the neck mass revealed a metastasis from an adrenal carcinoma, which was stained positively with antibodies against cytochrome P450 and renin, establishing the diagnosis of a renin-producing adrenocortical carcinoma. Trilostane was effective in reducing serum cortisol levels, but mitotane was ineffective.

Original languageEnglish
Pages (from-to)119-125
Number of pages7
Journalendocrine journal
Volume47
Issue number2
DOIs
Publication statusPublished - 2000 Apr

Keywords

  • Adrenal carcinoma
  • Hypertension
  • Hypokalemia
  • Mitotane
  • Renin-producing tumor
  • Trilostane

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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