A case of prostatic adenocarcinoma with Paneth cell-like appearance

Yasuhiro Nakamura, Fumiyoshi Fujishima, Mika Watanabe, Shinji Taniuchi, Kazuyuki Ishida, Shigeto Ishidoya, Yoichi Arai, Hironobu Sasano

Research output: Contribution to journalArticlepeer-review

Abstract

Paneth cell-like appearance of prostatic carcinoma cells with eosinophilic cytoplasmic granules is rarely reported, and is known to be associated with neuroendocrine differentiation of carcinoma cells. We report a case of prostatic adenocarcinoma with Paneth cell-like appearance that was localized next to conventional adenocarcinoma, and demonstrate its neuroendocrine differentiation by using immuno-histochemical analysis. Paneth cell-like appearance of prostatic carcinoma cells should be recognized and considered as a sign of neuroendocrine differentiation due to the possible association with resistance to hormone therapy.

Original languageEnglish
Pages (from-to)60-64
Number of pages5
JournalPolish Journal of Pathology
Volume62
Issue number1
Publication statusPublished - 2011 Jun 8

Keywords

  • Neuroendocrine differentiation
  • Paneth cell-like feature
  • Prostatic adenocarcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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