A case of marked efficacy of low-dose UFT against metastatic bladder cancer

Makoto Satoh, Osamu Nakano, Masaaki Kuwahara, Akihiro Ito, Yoichi Arai

Research output: Contribution to journalArticlepeer-review

Abstract

The two regimens of treatment consisted of either cisplatin and gemcitabine or methotrexate, vinblastine, doxorubicin and cisplatin (M-VAC), which has been widely adopted for muscle-invasive bladder cancer. But because of its potential toxicity, its tolerability has been troublesome, especially for very elderly patients. Herein, we report a bladder cancer case with multiple metastases which were controlled by low-dose UFT. At the same time, the chemosensitivity of 5-FU combined with uracyl or 5-chloro-2, 4-dihydroxypyridine (CDHP). Four invasive bladder cancer cell lines were evaluated with a collagen gel droplet embedded drug sensitivity test (CD-DST). Three of four cell lines showed an increasing sensitivity to 5-FU with the combination of uracil or CDHP. Examinations with CD-DST may provide important scientific evidence for determining suitable chemotherapy for patients with advanced bladder cancer.

Original languageEnglish
Pages (from-to)1029-1033
Number of pages5
JournalJapanese Journal of Cancer and Chemotherapy
Volume38
Issue number6
Publication statusPublished - 2011 Jun

Keywords

  • Bladder cancer
  • CD-DST
  • UFT

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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