A case of loxoprofen-induced pneumonitis pathologically resembling hypersensitivity pneumonitis

Masaki Tohyama; Yuichiro Tamaki; Masato Toyama; Tomohiko Ishimine; Akiko Miyazato; Atsushi Nakamoto; Takayuki Miyara; Futoshi Higa; Masao Tateyama; Kazuyoshi Kawakami; Hiroaki Nakamura; Atsushi Saito

A case of loxoprofen-induced pneumonitis pathologically resembling hypersensitivity pneumonitis

Masaki Tohyama, Yuichiro Tamaki, Masato Toyama, Tomohiko Ishimine, Akiko Miyazato, Atsushi Nakamoto, Takayuki Miyara, Futoshi Higa, Masao Tateyama, Kazuyoshi Kawakami, Hiroaki Nakamura, Atsushi Saito

Research output: Contribution to journal › Article

4 Citations (Scopus)

Abstract

A 66-year-old woman was admitted to our hospital because of high fever, general fatigue, hypoxemia and liver dysfunction. Chest radiographs showed diffuse interstitial shadows in both lungs. We suspected drug-induced pneumonitis because of her history of drug administration for upper respiratory infection. Her symptoms and findings were markedly decreased by discontinuation of the drugs. Transbronchial lung biopsy specimens showed infiltration of eosinophils and lymphocytes to the alveolar septa, granuloma with Langhans' giant cells, and Masson bodies in a manner suggestive of hypersensitivity pneumonitis. Drug lymphocyte stimulation tests were negative except for loxoprofen. There was no recurrence of systemic or respiratory symptoms during overnight stays at home. On the basis of these findings, we arrived at a diagnosis of drug-induced pneumonitis caused by loxoprofen.

Original language	English
Pages (from-to)	123-128
Number of pages	6
Journal	Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
Volume	40
Issue number	2
Publication status	Published - 2002 Feb
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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Tohyama, M., Tamaki, Y., Toyama, M., Ishimine, T., Miyazato, A., Nakamoto, A., Miyara, T., Higa, F., Tateyama, M., Kawakami, K., Nakamura, H., & Saito, A. (2002). A case of loxoprofen-induced pneumonitis pathologically resembling hypersensitivity pneumonitis. Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society, 40(2), 123-128.

A case of loxoprofen-induced pneumonitis pathologically resembling hypersensitivity pneumonitis. / Tohyama, Masaki; Tamaki, Yuichiro; Toyama, Masato; Ishimine, Tomohiko; Miyazato, Akiko; Nakamoto, Atsushi; Miyara, Takayuki; Higa, Futoshi; Tateyama, Masao; Kawakami, Kazuyoshi; Nakamura, Hiroaki; Saito, Atsushi.

In: Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society, Vol. 40, No. 2, 02.2002, p. 123-128.

Research output: Contribution to journal › Article

Tohyama, Masaki ; Tamaki, Yuichiro ; Toyama, Masato ; Ishimine, Tomohiko ; Miyazato, Akiko ; Nakamoto, Atsushi ; Miyara, Takayuki ; Higa, Futoshi ; Tateyama, Masao ; Kawakami, Kazuyoshi ; Nakamura, Hiroaki ; Saito, Atsushi. / A case of loxoprofen-induced pneumonitis pathologically resembling hypersensitivity pneumonitis. In: Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society. 2002 ; Vol. 40, No. 2. pp. 123-128.

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abstract = "A 66-year-old woman was admitted to our hospital because of high fever, general fatigue, hypoxemia and liver dysfunction. Chest radiographs showed diffuse interstitial shadows in both lungs. We suspected drug-induced pneumonitis because of her history of drug administration for upper respiratory infection. Her symptoms and findings were markedly decreased by discontinuation of the drugs. Transbronchial lung biopsy specimens showed infiltration of eosinophils and lymphocytes to the alveolar septa, granuloma with Langhans' giant cells, and Masson bodies in a manner suggestive of hypersensitivity pneumonitis. Drug lymphocyte stimulation tests were negative except for loxoprofen. There was no recurrence of systemic or respiratory symptoms during overnight stays at home. On the basis of these findings, we arrived at a diagnosis of drug-induced pneumonitis caused by loxoprofen.",

author = "Masaki Tohyama and Yuichiro Tamaki and Masato Toyama and Tomohiko Ishimine and Akiko Miyazato and Atsushi Nakamoto and Takayuki Miyara and Futoshi Higa and Masao Tateyama and Kazuyoshi Kawakami and Hiroaki Nakamura and Atsushi Saito",

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AU - Nakamoto, Atsushi

AU - Miyara, Takayuki

AU - Higa, Futoshi

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AB - A 66-year-old woman was admitted to our hospital because of high fever, general fatigue, hypoxemia and liver dysfunction. Chest radiographs showed diffuse interstitial shadows in both lungs. We suspected drug-induced pneumonitis because of her history of drug administration for upper respiratory infection. Her symptoms and findings were markedly decreased by discontinuation of the drugs. Transbronchial lung biopsy specimens showed infiltration of eosinophils and lymphocytes to the alveolar septa, granuloma with Langhans' giant cells, and Masson bodies in a manner suggestive of hypersensitivity pneumonitis. Drug lymphocyte stimulation tests were negative except for loxoprofen. There was no recurrence of systemic or respiratory symptoms during overnight stays at home. On the basis of these findings, we arrived at a diagnosis of drug-induced pneumonitis caused by loxoprofen.

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