TY - JOUR
T1 - A case of loxoprofen-induced pneumonitis pathologically resembling hypersensitivity pneumonitis
AU - Tohyama, Masaki
AU - Tamaki, Yuichiro
AU - Toyama, Masato
AU - Ishimine, Tomohiko
AU - Miyazato, Akiko
AU - Nakamoto, Atsushi
AU - Miyara, Takayuki
AU - Higa, Futoshi
AU - Tateyama, Masao
AU - Kawakami, Kazuyoshi
AU - Nakamura, Hiroaki
AU - Saito, Atsushi
N1 - Copyright:
This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
PY - 2002/2
Y1 - 2002/2
N2 - A 66-year-old woman was admitted to our hospital because of high fever, general fatigue, hypoxemia and liver dysfunction. Chest radiographs showed diffuse interstitial shadows in both lungs. We suspected drug-induced pneumonitis because of her history of drug administration for upper respiratory infection. Her symptoms and findings were markedly decreased by discontinuation of the drugs. Transbronchial lung biopsy specimens showed infiltration of eosinophils and lymphocytes to the alveolar septa, granuloma with Langhans' giant cells, and Masson bodies in a manner suggestive of hypersensitivity pneumonitis. Drug lymphocyte stimulation tests were negative except for loxoprofen. There was no recurrence of systemic or respiratory symptoms during overnight stays at home. On the basis of these findings, we arrived at a diagnosis of drug-induced pneumonitis caused by loxoprofen.
AB - A 66-year-old woman was admitted to our hospital because of high fever, general fatigue, hypoxemia and liver dysfunction. Chest radiographs showed diffuse interstitial shadows in both lungs. We suspected drug-induced pneumonitis because of her history of drug administration for upper respiratory infection. Her symptoms and findings were markedly decreased by discontinuation of the drugs. Transbronchial lung biopsy specimens showed infiltration of eosinophils and lymphocytes to the alveolar septa, granuloma with Langhans' giant cells, and Masson bodies in a manner suggestive of hypersensitivity pneumonitis. Drug lymphocyte stimulation tests were negative except for loxoprofen. There was no recurrence of systemic or respiratory symptoms during overnight stays at home. On the basis of these findings, we arrived at a diagnosis of drug-induced pneumonitis caused by loxoprofen.
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M3 - Article
C2 - 11974866
AN - SCOPUS:0036484876
VL - 40
SP - 123
EP - 128
JO - Respiratory Investigation
JF - Respiratory Investigation
SN - 2212-5345
IS - 2
ER -