A case of intravascular large B-cell lymphoma associated with transverse myelopathy

Masanori Seki, Tomohiro Sugawara, Katsutoshi Yamamoto, Taro Takahashi, Hideo Harigae

Research output: Contribution to journalArticlepeer-review


We present a 68-year-old man suffering from transverse myelopathy since May 2010. The spinal cord MRI showed a T2-hyperintense lesion invading the Th5 level spinal cord. Although the patient transiently responded to steroid-pulse therapy, his neurological symptoms degenerated three months after wards. On admission, he had an apparent hepatosplenomegaly, but no lymphadenopathy. A laboratory examination revealed bicytopenia and increased levels of LDH and soluble IL-2 receptors. Histological analysis of a skin biopsy specimen demonstrated proliferation of large atypical lymphoid cells positive for CD20 and CD79a in the small capillaries, leading to our diagnosis of intravascular large B-cell lymphoma (IVLBCL). Thus, the patient's progressive myelopathy was probably caused by IVLBCL invasion. The patient responded well to Rituximab-combined CHOP therapy (R-CHOP), and his neurological symptoms improved immediately. A spinal cord MRI showed the disappearance of the abnormal signal after two courses of R-CHOP. IVLBCL often presents with neurological manifestations, including transverse myelopathy.

Original languageEnglish
Pages (from-to)1885-1888
Number of pages4
JournalJapanese Journal of Cancer and Chemotherapy
Issue number11
Publication statusPublished - 2011 Nov


  • Intravascular large B-cell lymphoma
  • Rituximab
  • Transverse myelopathy

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'A case of intravascular large B-cell lymphoma associated with transverse myelopathy'. Together they form a unique fingerprint.

Cite this