The diagnosis of verrucous carcinoma is often not easy because its histopathology mimics verruca vulgaris and other benign diseases. We describe a 62-year-old Japanese man with verrucous carcinoma on his IV interdigital area. Magnetic resonance imaging disclosed tumor invasion up to the subcutis, which suggested malignancy. However, repeated biopsies did not show malignant features in the tumor. For treatment, we performed intra-arterial infusion chemotherapy and oral intake of 5-fluorouracil. After the tumor reduction, we excised the tumor with a sufficient margin. There was no evidence of tumor recurrence 1.5 years later.
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