A case of HER2-positive stage IV advanced gastric cancer treated with chemotherapy combined with trastuzumab

Kai Takaya, Ryosuke Takahashi, Satoru Honma, Shinichiro Horii, Hirokazu Takahashi, Motohisa Hagiwara, Masahiro Chin, Eiji Hashizume

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

We report a case of human epidermal growth factor receptor (HER) 2 positive stage IV advanced gastric cancer successfully treated with chemotherapy combined with trastuzumab. A 50-year-old man was diagnosed with type 3 gastric cancer complicated by liver and lymph node metastases. Owing to a HER2 immunohistochemistry tumor score of 3+, we initiated capecitabine plus CDDP plus trastuzumab chemotherapy. After 6 chemotherapy courses, computed tomography showed the liver metastasis had disappeared and the paraaortic lymph nodes had shrunk. We continued the capecitabine plus trastuzumab chemotherapy, which resulted in a progression free survival of 31 months. After 38 chemotherapy courses, the primary tumor progressed; therefore, the patient underwent surgery. Chemotherapy combined with trastuzumab can allow for resection of the primary tumor.

Original languageEnglish
Pages (from-to)1113-1116
Number of pages4
JournalJapanese Journal of Cancer and Chemotherapy
Volume43
Issue number9
Publication statusPublished - 2016 Sep

Keywords

  • Advanced gastric cancer
  • Conversion therapy
  • Trastuzumab

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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