A case of granulocyte-colony stimulating factor-producing esophageal squamous cell carcinoma treated with chemoradiation therapy

Kai Takaya, Nobuchika Niitsuma, Motohisa Hagiwara, Masahiro Chin, Ko Sugawara, Eiji Hashizume

Research output: Contribution to journalArticlepeer-review

Abstract

The patient was a 64-year-old man who presented with a hoarse voice, pharyngalgia, and high fever. Despite receiving therapy, he presented with dysphagia, and endoscopy revealed a tumor in the thoracic esophagus. A biopsy indicated squamous cell carcinoma. Despite no evidence of infection, laboratory findings revealed leukocytosis and high serum levels of granulocyte-colony stimulating factor (G-CSF). An immunohistochemical study showed positive staining for G-CSF in the tumor cells. Chemoradiation therapy (CRT) with 5-fluorouracil and cisplatin was administered, but his response to treatment was evaluated as progressive disease. Bone, brain, and liver metastases were detected consecutively, and he died 7 months after diagnosis. There are few reports of G-CSF-producing esophageal tumors, and the prognosis is very poor.

Original languageEnglish
Pages (from-to)1197-1200
Number of pages4
JournalJapanese Journal of Cancer and Chemotherapy
Volume45
Issue number8
Publication statusPublished - 2018 Aug
Externally publishedYes

Keywords

  • Esophageal carcinoma
  • G-csf-producing tumor

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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