A case of generalized pustular psoriasis treated by cyclosporin A during pregnancy

We describe a 23-year-old woman with generalized pustular psoriasis during pregnancy. She had been diagnosed at 14 years old and began to be treated with cyclosporin at 17 years old. When she became pregnant at 19 and 22 years old, she had an abortion because of worsening pustular psoriasis. This time, she was 3 months pregnant and visited our hospital for her therapy during the pregnancy. After our explanation about the risks including defective development of the baby and exacerbations of psoriasis, we continued the administration of cyclosporine, based on her and her husband's request. She had a normal male baby without any trouble. This case suggests that cyclosporin is one of optional therapies for patients with generalized pustular psoriasis during pregnancy when the therapeutic benefit exceeds the risk to the babies and mothers.