A case of fatal infectious mononucleosis presenting with fulminant hepatic failure associated with an extensive CD8-positive lymphocyte infiltration in the liver

Yusaku Tazawa, Fujihiko Nishinomiya, Hiroo Noguchi, Goro Takada, Shigeru Tsuchiya, Ryo Sumazaki, Hitoshi Takita, Hiroyuki Kanno, Masato Nose, Tasuke Konno

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

We describe a fatal case of infectious mononucleosis presenting with fulminant hepatic failure associated with extensive CD8-positive lymphocyte infiltration and diffuse karyorrhexis in the liver. Immunohistochemical analysis of mononuclear cells showed that Leu-2a (CD8)-positive lymphocytes were heavily distributed in the portal areas and the sinusoidal spaces, but Leu-3a (CD4)-, Leu-14 (CD22)-, or My 4 (CD14)-positive cells were undetectable in sections of the liver. Southern blot hybridization studies disclosed the presence of Epstein-Barr virus DNA fragments in the liver tissue. The unusual pathologic and immunologic responses observed in this case could not simply be explained by severe Epstein-Barr virus infection. Some superimposed factors should be considered.

Original languageEnglish
Pages (from-to)1135-1139
Number of pages5
JournalHuman Pathology
Volume24
Issue number10
DOIs
Publication statusPublished - 1993 Jan 1

Keywords

  • CD8-positive lymphocyte
  • Epstein-Barr virus
  • fulminant hepatic failure
  • infectious mononucleosis
  • karyorrhexis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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