A case of disseminated aspergillosis with smoldering adult T-cell leukemia

Natsuo Yamamoto, Takayuki Miyara, Kazuyoshi Kawakami, Hiroshi Kaneshima, Morikazu Akamine, Kaori Uezu, Yoshinobu Kouguchi, Masato Tohyama, Masaki Touyama, Tomohiko Ishimine, Atsushi Nakamoto, Futoshi Higa, Masao Tateyama, Atsushi Saito

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2 Citations (Scopus)


The patient was 39-year-old male who had been administrated 20 mg of prednisolone for control of chronic eosinophilic pneumonia. He consulted the hospital with fever, headache and gait disturbance. The laboratory data of peripheral blood revealed a smoldering adult T cell leukemia. Computed tomogram of the chest and MRI of the brain revealed a mass in the right middle lobe of the lung and a brain abscess in the left hemisphere respectively. Biopsied specimens from the lung and brain abscess showed an Aspergillus like fungus. In spite of placement of an Ommaya reservoir for administration of AMPH-B and control of intracranial pressure, he died. During the course, specific antigen and specific gene were not detected in the peripheral blood, and no viable organism was isolated from the specimens. Post mortem examination revealed multiple nodular lesions in the lung, parietal pleura, liver, heart and kidney. After autopsy, disseminated aspergillosis was confirmed through a tissue examination using nested PCR for Aspergillus DNA. In this case, we think that viable fungi could endure in the tissue while circulating Aspergillus markers remained undetectable.

Original languageEnglish
Pages (from-to)460-465
Number of pages6
JournalKansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases
Issue number6
Publication statusPublished - 2002 Jun
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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