TY - JOUR
T1 - A case of calvarial eosinophilic granuloma with rapid expansion and wide skull invasion
T2 - Immunohistochemical analysis of Ki-67
AU - Fujimura, Miki
AU - Nishijima, Michiharu
AU - Umezawa, Kunihiko
AU - Hayashi, Toshiaki
AU - Kaimori, Mitsuomi
PY - 2002/1/1
Y1 - 2002/1/1
N2 - A 15-year-old male visited our neurological service with progressive occipitalgia. Computed tomography showed an osteolytic lesion at the occipital cranium, which grew rapidly during a month. Magnetic resonance imaging showed the lesion as low intensity on T1- and high intensity on T2-weighted images. The mass was soft and successfully removed with surrounding cranium. Histological examination revealed an eosinophilic granuloma with wide skull invasion. Immunohistochemical analysis on the specimen disclosed Ki-67 expression with labeling index of 6.2%. Relatively high proliferative activity in the present case indicates that the local replication of Langerhans' cells as well as inflammatory response contributes to the expansion of calvarial eosinophilic granuloma. This is the first report demonstrating the result of Ki-67 expression on calvarial eosinophilic granuloma.
AB - A 15-year-old male visited our neurological service with progressive occipitalgia. Computed tomography showed an osteolytic lesion at the occipital cranium, which grew rapidly during a month. Magnetic resonance imaging showed the lesion as low intensity on T1- and high intensity on T2-weighted images. The mass was soft and successfully removed with surrounding cranium. Histological examination revealed an eosinophilic granuloma with wide skull invasion. Immunohistochemical analysis on the specimen disclosed Ki-67 expression with labeling index of 6.2%. Relatively high proliferative activity in the present case indicates that the local replication of Langerhans' cells as well as inflammatory response contributes to the expansion of calvarial eosinophilic granuloma. This is the first report demonstrating the result of Ki-67 expression on calvarial eosinophilic granuloma.
KW - Calvarium
KW - Eosinophilic granuloma
KW - Immunohistochemistry
KW - Ki-67
KW - MRI
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U2 - 10.1054/jocn.2001.0937
DO - 10.1054/jocn.2001.0937
M3 - Article
C2 - 11749023
AN - SCOPUS:0036151768
VL - 9
SP - 72
EP - 76
JO - Journal of Clinical Neuroscience
JF - Journal of Clinical Neuroscience
SN - 0967-5868
IS - 1
ER -