A case of aortitis caused by a granulocyte-colony-stimulating factor during chemotherapy for pancreatic cancer

Kento Miyazaki, Tatsuyuki Takadate, Fuyuhiko Motoi, Takashi Kamei, Takeshi Naitoh, Michiaki Unno

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Background: Pegfilgrastim, a long-acting granulocyte-colony-stimulating factor (G-CSF), has been used as prophylaxis for severe hematotoxicity induced by chemotherapy. We report a case of aortitis induced by pegfilgrastim administration during modified FOLFIRINOX (mFOLFIRINOX) chemotherapy for metastatic pancreatic cancer. Case report: A 65-year-old woman underwent a distal pancreatectomy for pancreatic tail cancer. Liver metastases appeared 2 years after the surgery. mFOLFIRINOX chemotherapy was started with prophylactic administration of pegfilgrastim. Eight days after the first administration and 6 days after administration of the 8th course, the patient developed a fever. The blood test results indicated severe inflammation. Computed tomography revealed a thickened aorta indicating aortitis. The symptoms rapidly improved with antibiotic therapy. We diagnosed aortitis induced by pegfilgrastim administration. Conclusion: Aortitis should be considered when a patient has unidentified inflammatory findings after receiving pegfilgrastim.

Original languageEnglish
Pages (from-to)851-853
Number of pages3
JournalJapanese Journal of Cancer and Chemotherapy
Volume47
Issue number5
Publication statusPublished - 2020 May

Keywords

  • Aortitis
  • G-CSF
  • Pancreatic cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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