A case of an elderly patient having advanced hepatocellular carcinoma with tumor thrombus in the inferior vena cava treated with chemo-radio-therapy--intraarterial infusion of weekly high dose 5-FU (WHF)

Shinichi Yabuuchi, Yu Katayose, Toshiki Rikiyama, Masaya Oikawa, Kuniharu Yamamoto, Toru Onogawa, Hiroki Hayashi, Mitsuhisa Muto, Michiaki Unno

Research output: Contribution to journalArticle

Abstract

The patient was an 81-year-old man, diagnosed with advanced huge hepatocellular carcinoma (HCC) with tumor thrombus extending into the inferior vena cava (Vv3), for which resection was judged impossible. The radio therapy (51 Gy) for tumor thrombus was carried out, and he received a weekly hepatic arterial infusion therapy (weekly high-dose 5-fluorouracil (5-FU)) for these legions. After 8 cycles, the CT scan revealed a minor response of the tumor (SD), and,the tumor marker reduced. After 10 months, these legions had markedly regressed (PR), the tumor thrombus in the inferior vena cava was not detectable. There were no severe side effects. Ten months since the start of chemo-radio therapy, the positron emission tomography (PET) revealed a metastatic tumor of the femoral bone in recurrence. In conclusion, some elderly patients of advanced HCC with tumor thrombus may obtain a long term survival through this treatment.

Original languageEnglish
Pages (from-to)1768-1770
Number of pages3
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume33
Issue number12
Publication statusPublished - 2006 Nov

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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