A case of aimed at healing by the open wound after sequestectomy to bisphosphonate-related osteonecrosis of the jaw

Fumitaka Terasawa, Atsuo Kaetsu, Atsumu Kouketsu, Hiroki Goto, Takamasa Shirozu, Mitsuharu Ino

Research output: Contribution to journalArticlepeer-review

Abstract

A 74-year-old woman was referred to our department by her dentist because of bone exposure and pus discharge of the right mandibular region. An oral examination revealed exposed devitalized bone, and pus discharge at a tooth-extraction socket of the right lower canine and lateral incisor, and a radiographic examination showed radiolucency of the right mandibular region. She had osteoporosis, and had received an oral bisphosphonate therapy. Bisphosphonate-induced osteonecrosis of the mandible was diagnosed. Bisphosphonate administration was terminated, and conservative therapy with oral administration of antibiotics and wound irrigation was carried out, but were not effective. After 4 months of conservative therapy, primary surgical therapy was carried out, because of radiographic examination suggested that a remove sequestrum had formed. Three months after primary surgery, An oral examination revealed exposed devitalized bone and teeth mobility of the left maxillary region. Eight months after primary surgery, secondary surgical therapy was carried out because of the same reason of primary surgery. Both of lesions were kept open wound after surgery. The postoperative course was uneventful.

Original languageEnglish
Pages (from-to)118-125
Number of pages8
JournalOral Therapeutics and Pharmacology
Volume34
Issue number3
Publication statusPublished - 2015
Externally publishedYes

Keywords

  • Bisphosphonate
  • Open wound
  • Osteonecrosis of the jaw
  • Sequestectomy

ASJC Scopus subject areas

  • Dentistry(all)
  • Pharmacology
  • Pharmacology (medical)

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