A case of ACTH-independent bilateral macronodular adrenal hyperplasia successfully treated by subtotal resection of the adrenal glands: Four-year follow-up

Yukio Kageyama, Kazuhiro Ishizaka, Masatora Iwashina, Hironobu Sasano, Kazunori Kihara

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

We report ACTH-independent bilateral macronodular adrenal hyperplasia (AIMAH) seen in a 48-year-old male with a history of rectal and skin cancer. Bilateral multiple adrenal nodular lesions on abdominal CT scans, elevated early morning plasma cortisol levels with undetectable plasma ACTH, increased 24-hour urinary free cortisol excretion, and loss of the normal circadian rhythm in cortisol secretion established the diagnosis of AIMAH. Subtotal resection of the adrenal glands preserving lower one third of the left side was performed, considering the unfavorable effects of total adrenalectomy on future treatment of his malignancies. He has been doing well for four years with normal plasma ACTH and cortisol levels. This case suggests that subtotal resection of the adrenal glands may be applicable to selected patients.

Original languageEnglish
Pages (from-to)227-229
Number of pages3
Journalendocrine journal
Volume49
Issue number2
DOIs
Publication statusPublished - 2002
Externally publishedYes

Keywords

  • ACTH-independent
  • Adrenal gland
  • Macronodular hyperplasia
  • Subtotal resection

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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