A caenorhabditis elegans insulin-like peptide, INS-17: Its physiological function and expression pattern

Yohei Matsunaga; Kensuke Nakajima; Keiko Gengyo-Ando; Shohei Mitani; Takashi Iwasaki; Tsuyoshi Kawano

doi:10.1271/bbb.120540

A caenorhabditis elegans insulin-like peptide, INS-17: Its physiological function and expression pattern

Yohei Matsunaga, Kensuke Nakajima, Keiko Gengyo-Ando, Shohei Mitani, Takashi Iwasaki, Tsuyoshi Kawano

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

The insulin/insulin-like growth factor-1 signaling pathway of Caenorhabditis elegans regulates larval diapause and adult lifespan through the sole insulin receptor-like protein, DAF-2. In the present study, the physiological function and expression pattern of INS-17, one of the C. elegans insulin-like peptides, were examined by disruption and overexpression of the gene, and by the use of a reporter gene. INS-17 might function as a DAF-2 antagonist in the regulation of larval diapause, but not of the adult lifespan. The reporter protein was intensively expressed during larval diapause. It showed a drastic decrease in amount after larval diapause, which matches well the physiological function of INS-17.

Original language	English
Pages (from-to)	2168-2172
Number of pages	5
Journal	Bioscience, Biotechnology and Biochemistry
Volume	76
Issue number	11
DOIs	https://doi.org/10.1271/bbb.120540
Publication status	Published - 2012
Externally published	Yes

Keywords

Antagonist
Caenorhabditis elegans
Insulinlike peptide
Larval diapause
Spatio-temporal expression

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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A caenorhabditis elegans insulin-like peptide, INS-17 : Its physiological function and expression pattern. / Matsunaga, Yohei; Nakajima, Kensuke; Gengyo-Ando, Keiko; Mitani, Shohei; Iwasaki, Takashi; Kawano, Tsuyoshi.

In: Bioscience, Biotechnology and Biochemistry, Vol. 76, No. 11, 2012, p. 2168-2172.

Research output: Contribution to journal › Article › peer-review

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