A caenorhabditis elegans insulin-like peptide, INS-17: Its physiological function and expression pattern

Yohei Matsunaga, Kensuke Nakajima, Keiko Gengyo-Ando, Shohei Mitani, Takashi Iwasaki, Tsuyoshi Kawano

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

The insulin/insulin-like growth factor-1 signaling pathway of Caenorhabditis elegans regulates larval diapause and adult lifespan through the sole insulin receptor-like protein, DAF-2. In the present study, the physiological function and expression pattern of INS-17, one of the C. elegans insulin-like peptides, were examined by disruption and overexpression of the gene, and by the use of a reporter gene. INS-17 might function as a DAF-2 antagonist in the regulation of larval diapause, but not of the adult lifespan. The reporter protein was intensively expressed during larval diapause. It showed a drastic decrease in amount after larval diapause, which matches well the physiological function of INS-17.

Original languageEnglish
Pages (from-to)2168-2172
Number of pages5
JournalBioscience, Biotechnology and Biochemistry
Volume76
Issue number11
DOIs
Publication statusPublished - 2012
Externally publishedYes

Keywords

  • Antagonist
  • Caenorhabditis elegans
  • Insulinlike peptide
  • Larval diapause
  • Spatio-temporal expression

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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