A BODIPY fluorescent probe with selective response for hypochlorous acid and its application in cell imaging

Lizhi Gai, John MacK, Hui Liu, Zheng Xu, Hua Lu, Zhifang Li

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)

Abstract

A boron-dipyrromethene (BODIPY) derivative with a hydroxymethyl group at the meso-position, 1, was synthesized, which exhibits a highly specific and rapid 'turn-off' response for HOCl during confocal fluorescence microscopy experiments under physiological conditions and in live cells. The formation of an electron-withdrawing formyl substituent upon oxidation results in highly efficient nonradiative decay of the S1 state and hence in a drastic decrease in fluorescence emission intensity.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalSensors and Actuators, B: Chemical
Volume182
DOIs
Publication statusPublished - 2013 Apr 3

Keywords

  • BODIPY
  • Cell image
  • Fluorescent probe
  • Hypochlorous acid
  • TD-DFT

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry

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