TY - JOUR
T1 - A 3D view of autotaxin
AU - Nishimasu, Hiroshi
AU - Ishitani, Ryuichiro
AU - Aoki, Junken
AU - Nureki, Osamu
N1 - Funding Information:
This work was supported by a grant for the National Project on Protein Structural and Functional Analyses, from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) to O.N. and J.A., by a National Institute of Biomedical Innovation grant to J.A., by MEXT grants to R.I. and O.N., and by the Japan Society for the Promotion of Science (JSPS), through the “Funding Program for World-Leading Innovative R&D on Science and Technology (FIRST Program)” initiated by the Council for Science and Technology Policy (CSTP), to O.N.
PY - 2012/3
Y1 - 2012/3
N2 - Autotaxin (ATX), also known as ectonucleotide pyrophosphatase/ phosphodiesterase 2 (Enpp2), is a secreted lysophospholipase D (lysoPLD) that generates the lipid mediator lysophosphatidic acid (LPA), which in turn activates G protein-coupled receptors to evoke various cellular responses. ATX is essential for normal development, is implicated in various physiological processes, and is also associated with pathological conditions such as cancer, pain and fibrosis. Despite its importance, the molecular mechanism of ATX-catalyzed LPA production has long been elusive. Recent structural analyses have provided new insights into the mechanisms of localized and regulated LPA production by ATX. This structural information will pave the way for further biochemical, biological and medical research.
AB - Autotaxin (ATX), also known as ectonucleotide pyrophosphatase/ phosphodiesterase 2 (Enpp2), is a secreted lysophospholipase D (lysoPLD) that generates the lipid mediator lysophosphatidic acid (LPA), which in turn activates G protein-coupled receptors to evoke various cellular responses. ATX is essential for normal development, is implicated in various physiological processes, and is also associated with pathological conditions such as cancer, pain and fibrosis. Despite its importance, the molecular mechanism of ATX-catalyzed LPA production has long been elusive. Recent structural analyses have provided new insights into the mechanisms of localized and regulated LPA production by ATX. This structural information will pave the way for further biochemical, biological and medical research.
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U2 - 10.1016/j.tips.2011.12.004
DO - 10.1016/j.tips.2011.12.004
M3 - Review article
C2 - 22277299
AN - SCOPUS:84857916518
VL - 33
SP - 138
EP - 145
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
SN - 0165-6147
IS - 3
ER -
