A 3D view of autotaxin

Hiroshi Nishimasu, Ryuichiro Ishitani, Junken Aoki, Osamu Nureki

Research output: Contribution to journalReview articlepeer-review

33 Citations (Scopus)

Abstract

Autotaxin (ATX), also known as ectonucleotide pyrophosphatase/ phosphodiesterase 2 (Enpp2), is a secreted lysophospholipase D (lysoPLD) that generates the lipid mediator lysophosphatidic acid (LPA), which in turn activates G protein-coupled receptors to evoke various cellular responses. ATX is essential for normal development, is implicated in various physiological processes, and is also associated with pathological conditions such as cancer, pain and fibrosis. Despite its importance, the molecular mechanism of ATX-catalyzed LPA production has long been elusive. Recent structural analyses have provided new insights into the mechanisms of localized and regulated LPA production by ATX. This structural information will pave the way for further biochemical, biological and medical research.

Original languageEnglish
Pages (from-to)138-145
Number of pages8
JournalTrends in Pharmacological Sciences
Volume33
Issue number3
DOIs
Publication statusPublished - 2012 Mar

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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