Aβ/Cu-catalyzed oxidation of cholesterol in 1,2-dipalmitoyl phosphatidylcholine liposome membrane

Toshinori Shimanouchi, Makoto Tasaki, Huong Thi Vu, Haruyuki Ishii, Noriko Yoshimoto, Hiroshi Umakoshi, Ryoichi Kuboi

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The amyloid β protein with 42 amino acid residues (Aβ), which is a causative protein of Alzheimer's disease (AD), forms the complex with copper (II) to induce the cholesterol oxidase-like activity by the proton transfer from the cholesterol. In this study, the oxidation of cholesterol by Aβ/Cu complex was investigated on the surface of the zwitterionic phospholipid liposome including the bound water advantageous for the enhancement of the proton transfer. The bound water was pooled by the formation of cholesterol-rich domain within liposomes. The resulting reactivity was enhanced by the proton transfer mediated by the bound water.

Original languageEnglish
Pages (from-to)145-148
Number of pages4
JournalJournal of Bioscience and Bioengineering
Volume109
Issue number2
DOIs
Publication statusPublished - 2010 Feb 1
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Amyloid β/Cu Complex
  • Cholesterol
  • Domain
  • Liposome

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology
  • Bioengineering

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