9,13-di-cis-Retinoic acid induces the production of tPA and activation of latent TGF-β via RARα in a human liver stellate cell line, LI90

Shoko Imai, Masataka Okuno, Hisataka Moriwaki, Yasutoshi Muto, Kazuhiro Murakami, Koichi Shudo, Yasuhiro Suzuki, Soichi Kojima

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)

Abstract

We studied the mechanism by which 9,13-di-cis-retinoic acid (9,13dcRA), a novel and endogenous stereoisomer of all-trans-RA, induces TGF-β formation in a human liver stellate cell line, LI90. 9,13dcRA induced the expression of RARα and RARβ, enhanced the production of tissue-type plasminogen activator (tPA), thereby, surface plasmin levels, and induced the activation of latent TGF-β. Similar effects were obtained with RARα-selective retinoid, but not with RARβ- or RARγ-selective retinoid, and the induction was inhibited by RARα-selective antagonist. These results suggest that 9,13dcRA up-regulates tPA expression, resulting in the formation of TGF-β by LI90 cells, at least in part, via induction and activation of RARα.

Original languageEnglish
Pages (from-to)102-106
Number of pages5
JournalFEBS Letters
Volume411
Issue number1
DOIs
Publication statusPublished - 1997 Jul 7

Keywords

  • 9,13-di-cis-Retinoic acid
  • Liver stellate cell
  • Proteolytic activation
  • RARα
  • TGF-β
  • tPA

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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