6,7-Dimethyllumazine as a potential ligand for selective recognition of adenine opposite an abasic site in DNA duplexes

Zhiqiang Ye; Burki Rajendar; Dai Qing; Seiichi Nishizawa; Norio Teramae

doi:10.1039/b816876h

6,7-Dimethyllumazine as a potential ligand for selective recognition of adenine opposite an abasic site in DNA duplexes

Zhiqiang Ye, Burki Rajendar, Dai Qing, Seiichi Nishizawa, Norio Teramae

SCI - Chemistry

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

6,7-Dimethyllumazine more selectively binds to adenine (A) base opposite the abasic site in DNA duplexes (5′-TCC AGX GCA AC-3′/3′-AGG TCN CGT TG-5′, X = AP site (Spacer C3), N = A, T, C and G) than the other three nucleobases with a dissociation constant K_d of ca. 1.0 μM; substituted methyl groups enhance the binding affinity to A and the selectivity for A over T, compared to the parent molecule, lumazine.

Original language	English
Pages (from-to)	6588-6590
Number of pages	3
Journal	Chemical Communications
Issue number	48
DOIs	https://doi.org/10.1039/b816876h
Publication status	Published - 2008 Dec 11

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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abstract = "6,7-Dimethyllumazine more selectively binds to adenine (A) base opposite the abasic site in DNA duplexes (5′-TCC AGX GCA AC-3′/3′-AGG TCN CGT TG-5′, X = AP site (Spacer C3), N = A, T, C and G) than the other three nucleobases with a dissociation constant Kd of ca. 1.0 μM; substituted methyl groups enhance the binding affinity to A and the selectivity for A over T, compared to the parent molecule, lumazine.",

author = "Zhiqiang Ye and Burki Rajendar and Dai Qing and Seiichi Nishizawa and Norio Teramae",

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AU - Ye, Zhiqiang

AU - Rajendar, Burki

AU - Qing, Dai

AU - Nishizawa, Seiichi

AU - Teramae, Norio

PY - 2008/12/11

Y1 - 2008/12/11

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AB - 6,7-Dimethyllumazine more selectively binds to adenine (A) base opposite the abasic site in DNA duplexes (5′-TCC AGX GCA AC-3′/3′-AGG TCN CGT TG-5′, X = AP site (Spacer C3), N = A, T, C and G) than the other three nucleobases with a dissociation constant Kd of ca. 1.0 μM; substituted methyl groups enhance the binding affinity to A and the selectivity for A over T, compared to the parent molecule, lumazine.

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6,7-Dimethyllumazine as a potential ligand for selective recognition of adenine opposite an abasic site in DNA duplexes

Abstract

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