Abstract
6,7-Dimethyllumazine more selectively binds to adenine (A) base opposite the abasic site in DNA duplexes (5′-TCC AGX GCA AC-3′/3′-AGG TCN CGT TG-5′, X = AP site (Spacer C3), N = A, T, C and G) than the other three nucleobases with a dissociation constant Kd of ca. 1.0 μM; substituted methyl groups enhance the binding affinity to A and the selectivity for A over T, compared to the parent molecule, lumazine.
| Original language | English |
|---|---|
| Pages (from-to) | 6588-6590 |
| Number of pages | 3 |
| Journal | Chemical Communications |
| Issue number | 48 |
| DOIs | |
| Publication status | Published - 2008 Dec 11 |
ASJC Scopus subject areas
- Catalysis
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- Chemistry(all)
- Surfaces, Coatings and Films
- Metals and Alloys
- Materials Chemistry
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Cite this
Ye, Z., Rajendar, B., Qing, D., Nishizawa, S., & Teramae, N. (2008). 6,7-Dimethyllumazine as a potential ligand for selective recognition of adenine opposite an abasic site in DNA duplexes. Chemical Communications, (48), 6588-6590. https://doi.org/10.1039/b816876h