The aldol reaction is one of the most important carbon-carbon bond-forming reactions in organic synthesis. Since the discovery of intra- and intermolecular aldol reactions catalyzed by proline, organocatalyst-mediated aldol reactions have been developed extensively. Currently, asymmetric organocatalytic aldol reactions can be classified into four major categories, differentiated by their reaction mechanisms: (1) enamine mechanisms; (2) ion-pair mechanisms; (3) chiral enolate mechanisms; and (4) electron acceptor activation by Brønsted acids. In this chapter, the authors describe these four types of aldol reactions; herein, the authors limit their discussion to reactions catalyzed by nonproline derivatives, whereas in the previous chapter, aldol reactions catalyzed by proline and proline derivatives are reviewed.
|Title of host publication||Comprehensive Chirality|
|Number of pages||32|
|Publication status||Published - 2012 Sep 1|
- Direct aldol reactions
- On water reactions
- Phase-transfer catalyst
ASJC Scopus subject areas